Epothilone-D 0.004 to 0.006μM on day4 R05 exp232 [The Human Chemical-Genetic Interaction Map Project]

Microtubule stabilizer

Class / Subclass 1: Organelle Function / Cytoskeletal Inhibitor
Class / Subclass 2: Cell Cycle / Microtubule Poison

Compound References

PubChem Name: Epothilone D
Synonyms: KOS 862
CAS #: 189453-10-9
PubChem CID: 447865
IUPAC: (4S,7R,8S,9S,13Z,16S)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-1-oxacyclohexadec-13-ene-2,6-dione
INCHI Name: InChI=1S/C27H41NO5S/c1-16-9-8-10-17(2)25(31)19(4)26(32)27(6,7)23(29)14-24(30)33-22(12-11-16)18(3)13-21-15-34-20(5)28-21/h11,13,15,17,19,22-23,25,29,31H,8-10,12,14H2,1-7H3/b16-11-,18-13+/t17-,19+,22-,23-,25-/m0/s1
INCHI Key: XOZIUKBZLSUILX-GIQCAXHBSA-N
Molecular Weight: 491.7
Canonical SMILES: CC1CCCC(=CCC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC2=CSC(=N2)C)C)C
Isomeric SMILES: C[C@H]1CCC/C(=C\\C[C@H](OC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]1O)C)(C)C)O)/C(=C/C2=CSC(=N2)C)/C)/C
Molecular Formula: C27H41NO5S

Compound Supplier

Supplier Name: N/A
Catalog #: N/A
Lot #: N/A

Compound Characterization

Characterization data not available.

Dose Response Curve

Platform ID: Epithilone-D
Min: -6.7452; Max: 86.8600

IC	Concentration (µM)
IC10	N/A
IC20	0.0027
IC30	0.0034
IC40	0.0041
IC50	0.0049
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 05
Dose: 4-6nM
Days of incubation: 8
Doublings: 7.2
Numbers of reads: 19604237

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
2/2	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
KATNA1	-3.55	<0.01
TACC3	-2.83	0.02
RSRC2	-2.60	0.41
GCLC	-2.48	0.24
BUB1B	-2.34	0.24
SEPSECS	-2.29	0.25
METTL20	-2.28	0.24
ZXDB	-2.26	0.24
ZBED2	-2.25	0.45
ACTL6A	-2.24	0.45
MGST1	-2.24	0.24
RIC8A	-2.23	0.24
WDR62	-2.21	0.24
EEF2	-2.21	0.67
PIAS4	-2.16	0.25
CMC2	-2.16	0.58
DMRTA2	-2.14	0.25
CHMP6	-2.12	0.41
NPRL3	-2.10	0.45
ALDH18A1	-2.09	0.41
KIF2A	-2.06	0.37
TRAPPC3	-2.05	0.37
DMP1	-2.04	0.41
VRK1	-2.03	0.41
ZNF704	-2.03	0.41
ASPHD1	-2.03	0.41
QRICH1	-2.03	0.48
SERINC3	-2.02	0.48
PSTK	-2.02	0.41
CD86	-1.98	0.45
CCDC116	1.98	0.50
BRINP2	1.99	0.43
KIAA1191	1.99	0.43
CYB561A3	2.01	0.47
DDT	2.01	0.43
POLR1A	2.01	0.68
ZNF688	2.02	0.46
CCDC30	2.03	0.46
OTOF	2.03	0.46
TRAPPC2L	2.08	0.43
AQR	2.09	0.70
CDKL3	2.10	0.43
LRIG1	2.12	0.43
PSMD11	2.15	0.43
VASN	2.15	0.43
TPX2	2.16	0.50
CLASP1	2.21	0.32
RAB44	2.21	0.50
C11orf84	2.21	0.43
KPNA1	2.22	0.32
SCARF2	2.23	0.43
EXOSC9	2.23	0.32
POLA1	2.23	0.68
SUPT6H	2.35	0.46
KLHL31	2.36	0.31
CEP192	2.49	0.43
NUP160	2.64	0.43
NDUFB7	2.71	0.32
KLRC3	2.73	0.05
DDTL	3.04	0.02

Screen	Correlation	Plot
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	0.073	View
Cabazitaxel 0.001μM R05 exp223	0.086	View
Epothilone-B 0.0015μM R05 exp231	0.085	View
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	0.074	View

Last modified: 2026/01/15 21:36
by 127.0.0.1