BN82002 4μM R07 exp340 [The Human Chemical-Genetic Interaction Map Project]

Inhibits CDC25 phosphatases, active against CDC25A/B/C isoforms

Class / Subclass 1: Cell Cycle / Phosphatase inhibitor
Class / Subclass 2: Signal Transduction / Phosphatase Inhibitor

Compound References

PubChem Name: Phenol, 4-(dimethylamino)-2-methoxy-6-((methyl(2-(4-nitrophenyl)ethyl)amino)methyl)-
Synonyms: N/A
CAS #: 396073-89-5
PubChem CID: 9798923
IUPAC: 4-(dimethylamino)-2-methoxy-6-[[methyl-[2-(4-nitrophenyl)ethyl]amino]methyl]phenol
INCHI Name: InChI=1S/C19H25N3O4/c1-20(2)17-11-15(19(23)18(12-17)26-4)13-21(3)10-9-14-5-7-16(8-6-14)22(24)25/h5-8,11-12,23H,9-10,13H2,1-4H3
INCHI Key: GOKYHQGRIIXMNE-UHFFFAOYSA-N
Molecular Weight: 359.4
Canonical SMILES: CN(C)C1=CC(=C(C(=C1)OC)O)CN(C)CCC2=CC=C(C=C2)[N+](=O)[O-]
Isomeric SMILES: N/A
Molecular Formula: C19H25N3O4

Compound Supplier

Supplier Name: Millipore
Catalog #: 217691
Lot #: 3028829

Compound Characterization

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C19H25N3O4 360.19178; found 360.19186

Dose Response Curve

Platform ID: BN82002
Min: -4.0820; Max: 99.8216

IC	Concentration (µM)
IC10	N/A
IC20	3.0294
IC30	3.6817
IC40	4.3505
IC50	5.0901
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 07
Dose: 4µM
Days of incubation: 8
Doublings: 6.8
Numbers of reads: 22454921

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
5/0	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
GCLM	-4.27	<0.01
SLC7A11	-3.30	<0.01
SEPHS1	-3.20	<0.01
SOD1	-2.88	0.02
GCLC	-2.83	0.01
NPRL3	-2.51	0.28
ACBD3	-2.24	0.28
DCAF15	-2.23	0.48
FAM194B	-2.06	0.57
SFMBT2	-2.06	0.57
PNRC2	-2.04	0.57
RNASEH2A	-2.02	0.57
RTCB	-2.01	0.57
TMC2	-2.00	0.57
ZRANB2	-1.95	0.57
QSOX1	-1.94	0.57
MTMR12	-1.94	0.57
PRRG4	-1.92	0.57
CBFB	-1.92	0.57
ZRSR2	-1.91	0.57
PFDN2	-1.90	0.71
C19orf70	-1.88	0.57
NPRL2	-1.88	0.57
TRAF5	-1.88	0.57
EMP2	-1.87	0.57
ERCC4	-1.86	0.58
LIG4	-1.85	0.71
PRKCG	-1.83	0.71
PPP6C	-1.83	0.71
WDR47	-1.82	0.70
DEFB115	1.86	0.78
DPPA2	1.86	0.78
CNTNAP2	1.88	0.78
BAGE4	1.89	0.79
BAGE5	1.89	0.79
BAGE2	1.89	0.79
BAGE3	1.89	0.79
BAGE	1.89	0.79
KPNB1	1.92	0.79
COL21A1	1.93	0.78
CCNA2	1.94	0.78
NSUN5	1.95	0.78
CASZ1	1.96	0.78
GCM1	1.96	0.76
ISCU	1.97	0.79
CLK3	2.01	0.69
PSMA7	2.03	0.79
MMRN1	2.06	0.65
PSMD2	2.08	0.76
MIR205HG	2.14	0.79
TTK	2.15	0.69
METTL21A	2.16	0.48
DUSP7	2.22	0.42
GAP43	2.23	0.59
CEP78	2.26	0.42
HSPA12B	2.35	0.42
LRRC30	2.38	0.42
MIER3	2.42	0.42
POLR2J	2.62	0.78
LIG1	2.80	0.79

GO Term	Fold Change	Genes
GATOR1 complex	614.04	NPRL3,NPRL2
glutathione metabolic process	47.23	GCLM,SLC7A11,SOD1,GCLC
negative regulation of neuron apoptotic process	19.68	GCLM,SOD1,GCLC,LIG4,PRKCG

Last modified: 2026/01/15 21:36
by 127.0.0.1