YM155 0.0002μM R01 exp61 [The Human Chemical-Genetic Interaction Map Project]

Inhibits expression of survivin, amongst other ascribed mechanisms

Class / Subclass 1: Gene Regulation / Transcription Inhibitor
Class / Subclass 2: Signal Transduction / Apoptosis Activator

Compound References

PubChem Name: Sepantronium bromide
Synonyms: Sepantronium bromide
CAS #: 781661-94-7
PubChem CID: 11178236
IUPAC: 1-(2-methoxyethyl)-2-methyl-3-(pyrazin-2-ylmethyl)benzo[f]benzimidazol-3-ium-4,9-dione;bromide
INCHI Name: InChI=1S/C20H19N4O3.BrH/c1-13-23(9-10-27-2)17-18(24(13)12-14-11-21-7-8-22-14)20(26)16-6-4-3-5-15(16)19(17)25;/h3-8,11H,9-10,12H2,1-2H3;1H/q+1;/p-1
INCHI Key: QBIYUDDJPRGKNJ-UHFFFAOYSA-M
Molecular Weight: 443.3
Canonical SMILES: CC1=[N+](C2=C(N1CCOC)C(=O)C3=CC=CC=C3C2=O)CC4=NC=CN=C4.[Br-]
Isomeric SMILES: N/A
Molecular Formula: C20H19BrN4O3

Compound Supplier

Supplier Name: Selleck Chemicals
Catalog #: S1130
Lot #: N/A

Compound Characterization

HRMS (ESI-TOF) m/z: (M)+ Calcd for C20 H19 N4 O3 363.14572; found 363.14685

Dose Response Curve

Platform ID: YM155
Min: 98.8935; Max: 99.2535

IC	Concentration (µM)
IC10	N/A
IC20	N/A
IC30	N/A
IC40	N/A
IC50	N/A
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 01
Dose: 0.2nM
Days of incubation: 8
Doublings: 7.0
Numbers of reads: 12549892

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
0/0	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
NSMCE1	-2.96	0.30
ZNF737	-2.89	0.48
MRPS5	-2.64	0.34
SART3	-2.62	0.42
YRDC	-2.59	0.74
CTPS1	-2.58	0.42
ARMCX3	-2.55	0.42
ERCC2	-2.53	0.42
OR13C3	-2.43	0.30
OR51S1	-2.42	0.48
NRDE2	-2.35	0.78
DERA	-2.30	0.48
VEZT	-2.28	0.42
CEP57	-2.26	0.48
C14orf178	-2.26	0.48
KIAA0391	-2.25	0.59
VPS25	-2.23	0.77
ATRX	-2.22	0.78
LEF1	-2.22	0.42
SLC7A9	-2.20	0.42
ENY2	-2.19	0.70
UBA3	-2.17	0.78
C8orf86	-2.11	0.59
RBX1	-2.10	0.78
FNBP1L	-2.08	0.78
PTDSS1	-2.07	0.42
CUL2	-2.05	0.77
DDX55	-2.05	0.70
RASA1	-2.05	0.78
ZNF600	-2.04	0.53
VKORC1L1	2.13	0.48
PSMD1	2.14	0.68
EIF5B	2.14	0.68
ZBTB49	2.15	0.48
SPAG5	2.16	0.50
POP1	2.19	0.49
N4BP2	2.20	0.62
COL19A1	2.20	0.49
ABCB8	2.20	0.62
ZNF345	2.23	0.28
FKBP1A	2.24	0.28
FBXL19	2.25	0.37
PDGFRA	2.25	0.28
ZNF114	2.25	0.62
PCDH1	2.27	0.37
NOP2	2.27	0.62
RPL32	2.29	0.68
RPL13	2.29	0.68
BCL2L12	2.31	0.50
MPHOSPH10	2.32	0.68
FAM178A	2.34	0.68
TRIM52	2.34	0.63
RALGDS	2.39	0.62
RUSC1	2.41	0.48
TESC	2.44	0.28
PSMD14	2.47	0.62
ZNF569	2.49	0.51
GPR33	2.68	0.28
HK1	2.96	0.10
TTK	3.28	0.10

Last modified: 2026/01/15 21:36
by 127.0.0.1