TMSB15B

Entrez Summary: N/A
UniProt Summary: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). May be involved in cell migration. {ECO:0000250, ECO:0000269|PubMed:19296525}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pyronaridine 1μM R06 exp295	-2.23
Aminopterin 0.005μM R07 exp335	-2.22
Tozasertib 0.1μM R07 exp414	-2.12
CVT-10216 0.1μM R06 exp278	-1.83
Bortezomib 0.05μM R00 exp7	-1.81
Dimethyl-Sulfoxide 1pc R03 exp120	-1.78
PU-H71 1μM R08 exp515	-1.78
GSK461364A 0.005μM R03 exp125	1.72
Mitomycin-C 0.06μM R08 exp503	1.72
Nutlin-3A 1.6μM R06 exp294	1.72
ONC212 0.15μM R08 exp513	1.73
Rifampicin 10μM R00 exp32	1.73
Golgicide-A 4μM R03 exp122	1.76
Cidofovir 10μM R07 exp345	1.76
VHL-ligand-1 20μM R07 exp421	1.89
L-74142 5μM R03 exp131	1.93
UM0131023 0.05μM R05 exp248	1.95
Epigallocatechin gallate 20μM R05 exp230	2
Calcipotriol 5μM R08 exp464	2.01
Quinacrine 2.5μM R03 exp146	2.01
AICAR 240μM R03 exp116	2.02
All-trans-Retinoic-Acid 8μM R07 exp333	2.03
Ibrutinib 10μM R08 exp442	2.09
JQ1 0.01μM R03 exp130	2.11
Phenformin 20μM R03 exp143	2.12
Nicotinamide 1000μM R03 exp101	2.14
S-DABN 8μM R03 exp112	2.17
Lenalidomide 20μM R07 exp375	2.19
QNZ 0.01μM R05 exp241	2.2
Rapamycin 2μM plus FK-506 5μM R07 exp308	2.24
Vincristine 0.0005μM R04 exp190	2.41
BI-2536 0.02μM R03 exp96	2.49
PNU96415E 10μM R03 exp145	2.59
THZ531 0.11 to 0.175μM on day4 R07 exp413	2.77
SGC0649 7μM R03 exp150	3.02
Pomalidomide 20μM R07 exp391	3.07

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

sequestering of actin monomers
actin monomer binding
negative regulation of actin filament polymerization
negative regulation of protein polymerization
maintenance of protein location in cell
maintenance of location in cell
maintenance of protein location
negative regulation of protein complex assembly
negative regulation of supramolecular fiber organization
negative regulation of cytoskeleton organization
maintenance of location
regulation of actin filament polymerization
regulation of actin polymerization or depolymerization
regulation of actin filament length
regulation of protein polymerization
actin filament organization
regulation of actin filament organization
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
cytoskeleton
negative regulation of organelle organization
regulation of cellular component size
regulation of actin filament-based process
cellular component
regulation of protein complex assembly
supramolecular fiber organization
actin cytoskeleton organization
positive regulation of cell migration
regulation of anatomical structure size
positive regulation of cell motility
positive regulation of cellular component movement
regulation of cytoskeleton organization
positive regulation of locomotion
actin filament-based process
negative regulation of cellular component organization
molecular function
regulation of cell migration
regulation of cell motility
regulation of cellular component biogenesis
regulation of locomotion