ADK

Gene Information

Official Symbol: ADK
Official Name: adenosine kinase
Aliases and Previous Symbols: N/A
Entrez ID: 132
UniProt: P55263
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hypoxia 5%O2 R04 exp191	-6.2
CB-5083 0.4μM R08 exp468	-4.02
Lead acetate 990μM R08 exp496	-3.58
Alpha-Amanitin 0.5μM R00 exp5	-3.42
CCCP 0.1μM R00 exp10	-2.95
Rifampicin 1μM R00 exp31	-2.69
LY2090314 0.003μM R08 exp499	-2.61
Pimelic-diphenylamide-106 0.5μM R00 exp27	-2.48
Mubritinib 0.2μM R01 exp48	-2.37
Cycloheximide 0.02μM R00 exp14	-2.36
LY2090314 0.003μM R08 exp500 no dilution day6	-2.23
QNZ 0.01μM R08 exp439	-2.16
FBS-Wisent 0.1 R07 exp426	-2.05
Phenformin 20μM R03 exp143	-2.02
Rotenone 0.07μM R08 exp431	-2.02
Phenformin 20μM R05 exp212	-2.01
Dinaciclib 0.007μM R07 exp355	-2
Wortmannin 5μM R00 exp38	-1.99
Metformin 100 to 150μM on day4 R04 exp170	-1.93
Nicotine 3000μM R08 exp510	-1.92
RO-3307 4.7μM R02 exp80	-1.9
Nicotinamide 2000μM R01 exp50	-1.88
Chloramphenicol 20μM R00 exp13	-1.85
Aphidicolin 0.04μM R06 exp263	-1.78
GSK2606414 1μM R05 exp236	-1.78
3-Bromopyruvate 7μM R04 exp175	-1.75
ONC212 0.15μM R08 exp513	-1.72
Radicicol 0.16μM R05 exp242	-1.71
Vincristine 0.0005μM R04 exp190	-1.71
Wortmannin 0.5μM R00 exp37	-1.7
UM0011500 10μM R05 exp246	1.71
2-Deoxy-D-glucose 800μM R05 exp214	1.73
GSK461364A 0.1μM R03 exp126	1.78
Temozolomide 200μM R04 exp189	1.82
BI-6727 0.04μM R03 exp98	1.86
BI-2536 0.02μM R03 exp96	2.09
Ribavirin 10μM R01 exp52	4.77
CyclicAMP 200μM R08 exp475	5.07
Ribavirin 10 to 15μM on day4 R04 exp160	8.18
AICAR 240μM R03 exp116	8.5
AICAR 240μM R05 exp211	8.5

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18790
Expression level (log2 read counts): 5.7

Expression Distribution

Gene	Correlation
NUDT2	0.636
ADSS	0.452
MTR	0.437
AK2	0.412

adenosine kinase activity
dATP biosynthetic process
AMP salvage
purine deoxyribonucleoside triphosphate biosynthetic process
purine deoxyribonucleotide biosynthetic process
dATP metabolic process
purine ribonucleoside salvage
AMP biosynthetic process
deoxyribonucleoside triphosphate biosynthetic process
purine nucleotide salvage
purine deoxyribonucleoside triphosphate metabolic process
purine deoxyribonucleotide metabolic process
deoxyribose phosphate biosynthetic process
2-deoxyribonucleotide biosynthetic process
AMP metabolic process
nucleotide salvage
deoxyribonucleotide biosynthetic process
purine-containing compound salvage
nucleoside salvage
deoxyribonucleoside triphosphate metabolic process
purine nucleoside monophosphate biosynthetic process
purine ribonucleoside monophosphate biosynthetic process
purine nucleoside biosynthetic process
purine ribonucleoside biosynthetic process
ribonucleoside biosynthetic process
2-deoxyribonucleotide metabolic process
deoxyribose phosphate metabolic process
ribonucleoside monophosphate biosynthetic process
deoxyribonucleotide metabolic process
cellular metabolic compound salvage
purine ribonucleoside monophosphate metabolic process
purine nucleoside monophosphate metabolic process
nucleoside biosynthetic process
glycosyl compound biosynthetic process
nucleoside monophosphate biosynthetic process
purine nucleoside triphosphate biosynthetic process
ribonucleoside monophosphate metabolic process
purine ribonucleoside metabolic process
nucleoside triphosphate biosynthetic process
purine nucleoside metabolic process