ARPC4

Gene Information

Official Symbol: ARPC4
Official Name: actin related protein 2/3 complex subunit 4
Aliases and Previous Symbols: N/A
Entrez ID: 10093
UniProt: P59998
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Clomiphene 4.4μM R02 exp68	-2.98
Thioridazine 5μM R08 exp530	-2.53
Bafilomycin-A1 0.009μM R08 exp454	-2.36
Vemurafenib 6.6μM R02 exp89	-2.36
Senexin-A 25μM R07 exp400	-2.26
Q15 1 to 2μM on day4 R04 exp164	-2.23
Vemurafenib 6.6μM R08 exp434	-2.15
NN-Dimethylsphingosine 2.5μM R08 exp508	-2
Chloroquine 32μM R08 exp470	-1.88
5-Fluorouracil 20μM R00 exp2	-1.86
BH1 1μM R04 exp169	-1.85
Bisphenol F 50μM R08 exp457	-1.72

Gene	Correlation
ARPC2	0.743
ACTR2	0.724
ACTR3	0.678
COMMD5	0.646
COMMD3	0.588
CCDC22	0.569
VPS29	0.568
COMMD7	0.565
COMMD10	0.534
COMMD9	0.512
CHKA	0.504
KIAA0196	0.5
COMMD2	0.482
RAB7A	0.465
COMMD4	0.459
ACSL4	0.459
USP32	0.453
CCDC53	0.449
MMD	0.448
ARPC3	0.448
KIAA1033	0.447
NCKAP1L	0.443
VPS45	0.436
VKORC1L1	0.43
GPR107	0.429
FLVCR1	0.427
MTMR9	0.419
PCYT2	0.406

Global Fraction of Cell Lines Where Essential: 123/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	9/28
blood	1/28
bone	1/26
breast	2/33
central nervous system	9/56
cervix	0/4
colorectal	4/17
esophagus	2/13
fibroblast	0/1
gastric	1/16
kidney	7/21
liver	9/20
lung	9/75
lymphocyte	2/16
ovary	8/26
pancreas	3/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	4/9
thyroid	0/2
upper aerodigestive	4/22
urinary tract	9/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 2076
Expression level (log2 read counts): 6.62

Expression Distribution

Arp2/3 protein complex
Arp2/3 complex-mediated actin nucleation
actin filament polymerization
actin nucleation
actin polymerization or depolymerization
site of double-strand break
protein binding, bridging
protein polymerization
ephrin receptor signaling pathway
positive regulation of actin filament polymerization
cell projection
structural constituent of cytoskeleton
positive regulation of protein polymerization
immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
Fc-gamma receptor signaling pathway involved in phagocytosis
Fc receptor mediated stimulatory signaling pathway
Fc-gamma receptor signaling pathway
regulation of actin filament polymerization
regulation of actin polymerization or depolymerization
regulation of actin filament length
positive regulation of supramolecular fiber organization
actin filament binding
positive regulation of cytoskeleton organization
regulation of protein polymerization
actin filament organization
Fc receptor signaling pathway
positive regulation of protein complex assembly
regulation of actin filament organization
phagocytosis
regulation of actin cytoskeleton organization
enzyme binding
regulation of supramolecular fiber organization
regulation of cellular component size
regulation of actin filament-based process
immune response-activating cell surface receptor signaling pathway
regulation of protein complex assembly
supramolecular fiber organization
immune response-regulating cell surface receptor signaling pathway
actin cytoskeleton organization
transmembrane receptor protein tyrosine kinase signaling pathway