BCL2L11

Gene Information

Official Symbol: BCL2L11
Official Name: BCL2 like 11
Aliases and Previous Symbols: N/A
Entrez ID: 10018
UniProt: O43521
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Etoposide 1μM R00 exp19	-2.05
AICAR 240μM R05 exp211	1.71
Cyclosporin-A 3μM R07 exp348	1.71
Cryptotanshinone 12μM R05 exp227	1.72
2-Deoxy-D-glucose 800μM R05 exp214	1.82
Lead acetate 2000μM R08 exp498 no dilution day6	1.82
Citral 75μM R06 exp275	1.85
Citral 50μM R06 exp274	1.86
Wortmannin 5μM R00 exp38	1.86
All-trans-Retinoic-Acid 40μM R07 exp334	1.9
Thimerosal 0.85μM R08 exp529	2
Sulforaphane 9μM R08 exp525	2.01
Olaparib 4μM R08 exp512	2.1
UM0129480 7μM R02 exp85	2.14
SNS-032 15μM R08 exp443	2.25
Thapsigargin 0.005μM R07 exp407	2.32
Aphidicolin 0.4μM R08 exp440	2.33
CR131-b 0.005μM R08 exp474	2.77
GSK626616 14μM R08 exp485	2.9
MS023 2μM R03 exp134	3.23
Benzoate 20000μM R08 exp456	3.4
JQ1 0.8μM R08 exp435	3.49
Hippuristanol 0.12μM R08 exp489 no dilution day6	3.57
MS023 7μM R03 exp135	3.97
AICAR 240μM R03 exp116	4.13
Hippuristanol 0.12μM R08 exp488	4.29
Ethanol 0.01 R05 exp234	5.72

Gene	Correlation
PMAIP1	0.556
RICTOR	0.515
VDAC2	0.488
MAPKAP1	0.476
CD19	0.471
PIK3CD	0.467
BAK1	0.46
GNAS	0.447
AKT2	0.446
PRRC2C	0.441
MARCH5	0.441
DGKD	0.431
MLST8	0.419
PDS5A	0.412
BIK	0.411
BMF	0.411

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14765
Expression level (log2 read counts): 6.42

Expression Distribution

Bim N
Bclx interact

positive regulation of autophagy in response to ER overload
positive regulation of apoptotic process by virus
cellular process regulating host cell cycle in response to virus
disruption by symbiont of host cell
positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction
positive regulation by symbiont of host apoptotic process
apoptotic process involved in embryonic digit morphogenesis
positive regulation by symbiont of host programmed cell death
killing by symbiont of host cells
modulation by virus of host apoptotic process
thymocyte apoptotic process
Bcl-2 family protein complex
modulation by organism of apoptotic process in other organism involved in symbiotic interaction
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
modulation of apoptotic process in other organism
modulation of programmed cell death in other organism
modulation by symbiont of host apoptotic process
modulation of programmed cell death in other organism involved in symbiotic interaction
positive regulation of IRE1-mediated unfolded protein response
B cell apoptotic process
modulation by symbiont of host programmed cell death
post-embryonic animal organ morphogenesis
positive regulation of fibroblast apoptotic process
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of protein homooligomerization
ER overload response
post-embryonic animal morphogenesis
regulation of IRE1-mediated unfolded protein response
killing of cells in other organism involved in symbiotic interaction
positive regulation of endoplasmic reticulum unfolded protein response
disruption of cells of other organism involved in symbiotic interaction
T cell apoptotic process
mitochondrial outer membrane permeabilization
positive regulation of killing of cells of other organism
regulation of developmental pigmentation
post-embryonic animal organ development
positive regulation of mitochondrial membrane permeability involved in apoptotic process
apoptotic process involved in morphogenesis
regulation of fibroblast apoptotic process
regulation of killing of cells of other organism