CARM1

Gene Information

Official Symbol: CARM1
Official Name: coactivator associated arginine methyltransferase 1
Aliases and Previous Symbols: N/A
Entrez ID: 10498
UniProt: Q86X55
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg- 2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA- stabilizing properties and the half-life of their target mRNAs. {ECO:0000269|PubMed:16497732, ECO:0000269|PubMed:19405910}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LY2090314 0.003μM R08 exp499	-2.91
Cerivastatin 0.15μM R05 exp226	-2.9
Benzoate 10000μM R08 exp455	-2.48
THZ531 0.11 to 0.125μM on day4 R07 exp410	-2.4
Lead acetate 2000μM R08 exp497	-2.35
UM0125461 0.74μM R02 exp84	-2.32
Fluvastatin 2.2μM R06 exp282	-2.29
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-2.19
Arsenate 40μM R06 exp264	-2.02
THZ531 0.11μM R07 exp409	-1.99
proTAME 5μM R04 exp187	-1.98
ML-792 0.2μM R08 exp505	-1.97
NFN1 0.4μM R03 exp99	-1.96
LY2090314 0.003μM R08 exp500 no dilution day6	-1.91
Apcin 25μM plus proTAME 2μM R04 exp177	-1.89
Docosahexaenoic-acid 50μM R07 exp356	-1.84
MS023 2μM R03 exp134	-1.83
Thapsigargin 0.005μM R07 exp407	-1.83
5-Azacytidine 2μM R07 exp330	-1.8
Pomalidomide 20μM R07 exp391	-1.8
Alpha-Amanitin 0.5μM R00 exp5	-1.79
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-1.71
AICAR 240μM R05 exp211	1.72
TRAIL 5ng/ml R00 exp35	1.82
GSK591 2.6μM R03 exp128	1.83
GSK461364A 0.005μM R03 exp125	1.93
Clomiphene 4.4μM R02 exp68	1.96
TRAIL 50ng/ml R00 exp36	1.97
Bafilomycin-A1 0.009μM R08 exp454	2.17
Vemurafenib 6.6μM R02 exp89	3.5
Diepoxybutane 3μM R07 exp354	3.53
Vemurafenib 6.6μM R08 exp434	4.2

Global Fraction of Cell Lines Where Essential: 7/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	1/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8114
Expression level (log2 read counts): 6.23

Expression Distribution

PrmA
MTS
Methyltransf 18
Methyltransf 9
CARM1
PRMT5

histone methyltransferase activity (H3-R17 specific)
histone H3-R17 methylation
regulation of growth plate cartilage chondrocyte proliferation
histone H3-R2 methylation
protein-arginine N-methyltransferase activity
protein-arginine omega-N asymmetric methyltransferase activity
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
regulation of mRNA binding
histone-arginine N-methyltransferase activity
peptidyl-arginine omega-N-methylation
protein methyltransferase activity
regulation of RNA binding
histone methyltransferase activity
peptidyl-arginine N-methylation
histone arginine methylation
peptidyl-arginine methylation
lysine-acetylated histone binding
intracellular estrogen receptor signaling pathway
regulation of bone development
protein localization to chromatin
peptidyl-arginine modification
negative regulation of dendrite development
regulation of intracellular estrogen receptor signaling pathway
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
intracellular signal transduction involved in G1 DNA damage checkpoint
signal transduction involved in mitotic DNA integrity checkpoint
signal transduction involved in mitotic G1 DNA damage checkpoint
signal transduction involved in mitotic cell cycle checkpoint
signal transduction involved in mitotic DNA damage checkpoint
positive regulation of fat cell differentiation
protein localization to chromosome
mitotic G1 DNA damage checkpoint
mitotic G1/S transition checkpoint
G1 DNA damage checkpoint
nuclear receptor transcription coactivator activity
intracellular steroid hormone receptor signaling pathway
regulation of cartilage development
signal transduction involved in DNA damage checkpoint
RNA polymerase II transcription factor complex
signal transduction involved in DNA integrity checkpoint