COX18

Entrez Summary: N/A
UniProt Summary: Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT-CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT-CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase). {ECO:0000269|PubMed:16911509, ECO:0000269|PubMed:28330871}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UM0125461 0.74μM R02 exp84	1.8
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	1.82
Temozolomide 200μM R04 exp189	1.83
Campthothecin 0.001μM R06 exp270	1.86
Resveratrol 16μM R03 exp147	1.87
Azithromycin 100μM R08 exp452	1.93
MK2206 4μM R08 exp504	1.97
iCRT14 30μM R08 exp492	2.08
Ribavirin 10 to 15μM on day4 R04 exp160	2.15
Ribavirin 10μM R01 exp52	2.24
Oligomycin-A 2μM R00 exp25	2.53

Global Fraction of Cell Lines Where Essential: 6/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	1/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

membrane insertase activity
protein insertion into mitochondrial inner membrane from matrix
protein insertion into membrane from inner side
protein insertion into mitochondrial inner membrane
establishment of protein localization to mitochondrial membrane
mitochondrial respiratory chain complex IV assembly
protein insertion into mitochondrial membrane
respiratory chain complex IV assembly
cytochrome complex assembly
integral component of mitochondrial inner membrane
protein insertion into membrane
inner mitochondrial membrane organization
protein targeting to mitochondrion
establishment of protein localization to mitochondrion
protein localization to mitochondrion
mitochondrial respiratory chain complex assembly
mitochondrial membrane organization
mitochondrial transport
establishment of protein localization to membrane
protein targeting
establishment of protein localization to organelle
mitochondrion organization
protein localization to membrane
protein localization to organelle
cellular protein-containing complex assembly
membrane organization
intracellular protein transport
protein transport
intracellular transport
peptide transport
protein-containing complex assembly
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
protein-containing complex subunit organization