CTU2

Entrez Summary: N/A
UniProt Summary: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. {ECO:0000255|HAMAP-Rule:MF_03054, ECO:0000269|PubMed:19017811}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vemurafenib 6.6μM R02 exp89	-2.34
Erlotinib 10μM R05 exp216	-2.09
Tubastatin-A 2.5μM R07 exp417	-1.8
GSK2606414 1μM R05 exp236	-1.77
Taxol 0.002μM R01 exp54	-1.76
NMS-873 0.07μM R07 exp380	1.74
Chloramphenicol 20μM R00 exp13	1.76
Latrunculin-B 10μM R07 exp374	1.78
Mubritinib 0.2μM R02 exp65	1.78
IU1-C 25μM R04 exp183	1.81
CR131-b 0.005μM R08 exp474	1.82
FK-506 30μM R07 exp359	1.86
Sulforaphane 9μM R08 exp526 no dilution day6	1.94
Citral 50μM R06 exp274	2
CoCl2 18μM R07 exp346	2
D-Fructose 10000μM R06 exp279	2.1
Hippuristanol 0.12μM R08 exp488	2.11
MS023 7μM R03 exp135	2.14
6-Thio-2-deoxyguanosine 2μM R06 exp259	2.18
Rotenone 0.07μM R08 exp431	2.18
QNZ 0.01μM R08 exp439	2.35
Artemisinin 50μM R08 exp450	2.37
QNZ 0.01μM R05 exp241	2.37
2-Deoxy-D-glucose 800μM R05 exp214	2.81
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.91
MS023 2μM R03 exp134	2.93
MLN-4924 0.2μM R00 exp21	3.52

Global Fraction of Cell Lines Where Essential: 303/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	14/28
blood	8/28
bone	9/26
breast	9/33
central nervous system	24/56
cervix	0/4
colorectal	8/17
esophagus	5/13
fibroblast	1/1
gastric	5/16
kidney	8/21
liver	14/20
lung	29/75
lymphocyte	3/16
ovary	13/26
pancreas	12/24
peripheral nervous system	2/16
plasma cell	5/15
prostate	0/1
skin	12/24
soft tissue	4/9
thyroid	0/2
upper aerodigestive	10/22
urinary tract	18/29
uterus	2/5

Expression Distribution

sulfurtransferase activity
protein urmylation
tRNA wobble position uridine thiolation
tRNA thio-modification
nucleotidyltransferase activity
tRNA wobble uridine modification
tRNA wobble base modification
tRNA binding
tRNA modification
tRNA processing
RNA modification
tRNA metabolic process
ncRNA processing
ncRNA metabolic process
protein-containing complex
protein modification by small protein conjugation
RNA processing
protein modification by small protein conjugation or removal
RNA metabolic process
gene expression