DDX46

Entrez Summary: N/A
UniProt Summary: Plays an essential role in splicing, either prior to, or during splicing A complex formation. {ECO:0000269|PubMed:12234937}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ammonium tetrathiomolybdate 10μM R08 exp448	-2.28
Wortmannin 5μM R00 exp38	-2.27
42°C R08 exp539	-2.01
S-trityl-L-cysteine 0.5μM R05 exp243	-1.89
Pyridostatin 4μM R05 exp240	1.7
Dexamethasone 0.006μM R07 exp351	1.72
Rapamycin 0.001μM R08 exp429	1.72
Bafilomycin-A1 0.009μM R08 exp454	1.74
Colchicine 0.009μM R05 exp215	1.77
Cytochalasin-B 5μM R07 exp349	1.77
UM0011500 5μM R05 exp245	1.79
Docosahexaenoic-acid 50μM R07 exp356	1.82
ABT-702 5μM R07 exp318	1.93
Dihydrosphingosine 8μM R08 exp476	2.17
All-trans-Retinoic-Acid 40μM R07 exp334	2.19
LJH685 5μM R02 exp73	2.29
CAY10603 0.55μM R08 exp467	2.35
Epothilone-B 0.0015μM R05 exp231	2.52
Genistein 15μM R07 exp360	2.63
Wiskostatin 3μM R07 exp422	2.73
Epigallocatechin gallate 20μM R05 exp230	3.53

Global Fraction of Cell Lines Where Essential: 12/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	2/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Helicase C
DEAD

Cajal body
RNA helicase activity
fibrillar center
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
RNA splicing
nuclear speck
mRNA processing
mRNA metabolic process
RNA processing
RNA binding
ATP binding
RNA metabolic process
membrane
gene expression