MEF2A
Gene Information
- Official Symbol: MEF2A
- Official Name: myocyte enhancer factor 2A
- Aliases and Previous Symbols: N/A
- Entrez ID: 4205
- UniProt: Q02078
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| SRF-TF |
| HJURP C |
GO Terms
| ERK5 cascade |
| ventricular cardiac myofibril assembly |
| ventricular cardiac muscle cell development |
| ventricular cardiac muscle cell differentiation |
| mitochondrion distribution |
| mitochondrial genome maintenance |
| cardiac myofibril assembly |
| histone acetyltransferase binding |
| positive regulation of cardiac muscle hypertrophy |
| positive regulation of muscle hypertrophy |
| activating transcription factor binding |
| positive regulation of glucose import |
| positive regulation of glucose transmembrane transport |
| mitochondrion localization |
| SMAD binding |
| regulation of glucose import |
| regulation of cardiac muscle hypertrophy |
| dendrite morphogenesis |
| regulation of muscle hypertrophy |
| cardiac muscle cell development |
| RNA polymerase II transcription factor binding |
| cardiac cell development |
| myofibril assembly |
| regulation of glucose transmembrane transport |
| cellular response to calcium ion |
| regulation of muscle adaptation |
| positive regulation of muscle cell differentiation |
| cardiac muscle cell differentiation |
| cardiac conduction |
| dendrite development |
| cellular component assembly involved in morphogenesis |
| histone deacetylase binding |
| actomyosin structure organization |
| cardiocyte differentiation |
| multicellular organismal signaling |
| striated muscle cell development |
| muscle cell development |
| response to calcium ion |
| regulation of muscle cell differentiation |
| cardiac muscle tissue development |
| cellular response to metal ion |
| striated muscle cell differentiation |
| positive regulation of transmembrane transport |
| transcription factor complex |
| cellular response to inorganic substance |
| regulation of muscle system process |
| nuclear chromatin |
| regulation of heart contraction |
| muscle cell differentiation |
| striated muscle tissue development |
| transcription coactivator activity |
| regulation of blood circulation |
| muscle organ development |
| muscle tissue development |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| response to metal ion |
| MAPK cascade |
| signal transduction by protein phosphorylation |
| chromatin binding |
| sequence-specific DNA binding |
| cell morphogenesis involved in neuron differentiation |
| mitochondrion organization |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| supramolecular fiber organization |
| protein kinase binding |
| muscle structure development |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| protein heterodimerization activity |
| cell projection morphogenesis |
| actin cytoskeleton organization |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| cell part morphogenesis |
| heart development |
| response to inorganic substance |
| cell morphogenesis involved in differentiation |
| regulation of transmembrane transport |
| actin filament-based process |
| organelle localization |
| regulation of system process |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| neuron projection development |
| DNA-binding transcription factor activity |
| cell morphogenesis |
| organelle assembly |
| neuron development |
| cellular component morphogenesis |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| apoptotic process |
| positive regulation of cell differentiation |
| protein phosphorylation |
| positive regulation of transport |
| neuron differentiation |
| programmed cell death |
| cell death |
| nucleobase-containing compound biosynthetic process |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| phosphorylation |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| RNA metabolic process |
| intracellular signal transduction |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| macromolecule biosynthetic process |
| regulation of cell differentiation |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3899
- Expression level (log2 read counts): 7.57
Expression Distribution
MEF2A Expression in NALM6 Cells: 7.57
