ORC3
Gene Information
- Official Symbol: ORC3
- Official Name: origin recognition complex subunit 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 23595
- UniProt: Q9UBD5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| ORC3 N |
GO Terms
| DNA replication preinitiation complex |
| nuclear pre-replicative complex |
| origin recognition complex |
| pre-replicative complex assembly involved in cell cycle DNA replication |
| pre-replicative complex assembly |
| pre-replicative complex assembly involved in nuclear cell cycle DNA replication |
| nuclear origin of replication recognition complex |
| DNA replication origin binding |
| DNA replication initiation |
| nuclear DNA replication |
| cell cycle DNA replication |
| neural precursor cell proliferation |
| nuclear chromosome, telomeric region |
| G1/S transition of mitotic cell cycle |
| cell cycle G1/S phase transition |
| DNA-dependent DNA replication |
| protein-DNA complex assembly |
| DNA replication |
| protein-DNA complex subunit organization |
| mitotic cell cycle phase transition |
| cell cycle phase transition |
| nuclear body |
| cell population proliferation |
| mitotic cell cycle process |
| mitotic cell cycle |
| DNA metabolic process |
| cellular protein-containing complex assembly |
| cell cycle process |
| cell cycle |
| protein-containing complex assembly |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| protein-containing complex subunit organization |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 6/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 2/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1694
- Expression level (log2 read counts): 5.34
Expression Distribution
ORC3 Expression in NALM6 Cells: 5.34
