PPP3CA
Gene Information
- Official Symbol: PPP3CA
- Official Name: protein phosphatase 3 catalytic subunit alpha
- Aliases and Previous Symbols: N/A
- Entrez ID: 5530
- UniProt: Q08209
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1. {ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:18838687}.
Pfam Domains GO Terms
Pfam Domains
| Metallophos |
GO Terms
| positive regulation of cardiac muscle adaptation |
| positive regulation of cardiac muscle hypertrophy in response to stress |
| positive regulation of connective tissue replacement |
| regulation of connective tissue replacement |
| calcineurin complex |
| calmodulin-dependent protein phosphatase activity |
| positive regulation of muscle adaptation |
| regulation of cardiac muscle adaptation |
| regulation of cardiac muscle hypertrophy in response to stress |
| negative regulation of chromatin binding |
| transition between fast and slow fiber |
| slit diaphragm |
| negative regulation of production of miRNAs involved in gene silencing by miRNA |
| calcineurin-NFAT signaling cascade |
| negative regulation of gene silencing by miRNA |
| muscle hypertrophy in response to stress |
| cardiac muscle adaptation |
| cardiac muscle hypertrophy in response to stress |
| regulation of skeletal muscle adaptation |
| calcineurin-mediated signaling |
| peptidyl-serine dephosphorylation |
| negative regulation of posttranscriptional gene silencing |
| postsynaptic modulation of chemical synaptic transmission |
| negative regulation of dendrite morphogenesis |
| negative regulation of gene silencing by RNA |
| regulation of production of miRNAs involved in gene silencing by miRNA |
| regulation of production of small RNA involved in gene silencing by RNA |
| regulation of chromatin binding |
| inositol phosphate-mediated signaling |
| skeletal muscle fiber development |
| cyclosporin A binding |
| striated muscle adaptation |
| myotube cell development |
| cardiac muscle hypertrophy |
| negative regulation of dendrite development |
| striated muscle hypertrophy |
| positive regulation of cardiac muscle hypertrophy |
| positive regulation of tissue remodeling |
| positive regulation of muscle hypertrophy |
| response to amphetamine |
| muscle adaptation |
| muscle hypertrophy |
| skeletal muscle tissue regeneration |
| negative regulation of gene silencing |
| Wnt signaling pathway, calcium modulating pathway |
| negative regulation of insulin secretion |
| negative regulation of peptide hormone secretion |
| response to amine |
| response to bronchodilator |
| cytoplasmic side of plasma membrane |
| regulation of cardiac muscle hypertrophy |
| myotube differentiation |
| drug binding |
| muscle fiber development |
| regulation of muscle hypertrophy |
| excitatory postsynaptic potential |
| negative regulation of hormone secretion |
| tissue regeneration |
| protein serine/threonine phosphatase activity |
| chemical synaptic transmission, postsynaptic |
| multicellular organismal response to stress |
| cellular response to glucose stimulus |
| cellular response to hexose stimulus |
| cellular response to monosaccharide stimulus |
| regulation of tissue remodeling |
| cellular response to carbohydrate stimulus |
| Schaffer collateral - CA1 synapse |
| regulation of muscle adaptation |
| regulation of gene silencing by miRNA |
| cellular glucose homeostasis |
| regulation of gene silencing by RNA |
| regulation of posttranscriptional gene silencing |
| regulation of dendrite morphogenesis |
| protein import into nucleus |
| negative regulation of cell morphogenesis involved in differentiation |
| sarcolemma |
| regulation of postsynaptic membrane potential |
| positive regulation of endocytosis |
| import into nucleus |
| G1/S transition of mitotic cell cycle |
| cell cycle G1/S phase transition |
| skeletal muscle tissue development |
| regulation of gene silencing |
| negative regulation of protein secretion |
| Z disc |
| skeletal muscle organ development |
| non-canonical Wnt signaling pathway |
| striated muscle cell development |
| response to glucose |
| negative regulation of peptide secretion |
| protein import |
| response to hexose |
| calcium-mediated signaling |
| muscle cell development |
| dendritic spine |
| response to monosaccharide |
| regulation of dendrite development |
| response to calcium ion |
| negative regulation of neuron projection development |
| regeneration |
| protein dimerization activity |
| protein localization to nucleus |
| negative regulation of binding |
| response to carbohydrate |
| Fc-epsilon receptor signaling pathway |
| regulation of insulin secretion |
| negative regulation of protein transport |
| negative regulation of cell projection organization |
| glucose homeostasis |
| negative regulation of establishment of protein localization |
| carbohydrate homeostasis |
| striated muscle cell differentiation |
| calmodulin binding |
| negative regulation of secretion by cell |
| regulation of endocytosis |
| regulation of peptide hormone secretion |
| protein dephosphorylation |
| negative regulation of neuron differentiation |
| negative regulation of secretion |
| T cell activation |
| regulation of muscle system process |
| Fc receptor signaling pathway |
| muscle cell differentiation |
| calcium ion transport |
| positive regulation of DNA-binding transcription factor activity |
| nucleocytoplasmic transport |
| nuclear transport |
| regulation of hormone secretion |
| mitotic cell cycle phase transition |
| aging |
| cell cycle phase transition |
| striated muscle tissue development |
| negative regulation of neurogenesis |
| divalent metal ion transport |
| muscle organ development |
| muscle tissue development |
| muscle system process |
| response to xenobiotic stimulus |
| divalent inorganic cation transport |
| regulation of cell morphogenesis involved in differentiation |
| dephosphorylation |
| negative regulation of nervous system development |
| negative regulation of cell development |
| second-messenger-mediated signaling |
| glutamatergic synapse |
| enzyme binding |
| Wnt signaling pathway |
| cell-cell signaling by wnt |
| response to metal ion |
| regulation of binding |
| lymphocyte activation |
| developmental growth |
| growth |
| cellular response to drug |
| positive regulation of cell adhesion |
| chemical synaptic transmission |
| anterograde trans-synaptic signaling |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of DNA-binding transcription factor activity |
| regulation of membrane potential |
| establishment of protein localization to organelle |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| synaptic signaling |
| regulation of protein secretion |
| muscle structure development |
| wound healing |
| immune response-regulating cell surface receptor signaling pathway |
| negative regulation of transport |
| protein heterodimerization activity |
| regulation of cell morphogenesis |
| regulation of peptide secretion |
| regulation of neuron projection development |
| positive regulation of cell migration |
| response to toxic substance |
| positive regulation of cell motility |
| response to inorganic substance |
| regulation of hormone levels |
| positive regulation of cellular component movement |
| regulation of vesicle-mediated transport |
| positive regulation of locomotion |
| response to wounding |
| regulation of system process |
| immune response-regulating signaling pathway |
| mitotic cell cycle process |
| metal ion transport |
| regulation of neuron differentiation |
| regulation of cell adhesion |
| mitotic cell cycle |
| regulation of plasma membrane bounded cell projection organization |
| negative regulation of cellular component organization |
| regulation of protein transport |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| calcium ion binding |
| protein localization to organelle |
| regulation of peptide transport |
| brain development |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| head development |
| regulation of secretion |
| regulation of neurogenesis |
| cation transport |
| regulation of cell migration |
| cellular homeostasis |
| regulation of cell motility |
| regulation of nervous system development |
| leukocyte activation |
| regulation of cell development |
| negative regulation of developmental process |
| central nervous system development |
| regulation of locomotion |
| positive regulation of transport |
| intracellular protein transport |
| regulation of cellular component movement |
| cell cycle process |
| response to organonitrogen compound |
| response to drug |
| regulation of protein localization |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| cell activation |
| response to nitrogen compound |
| chemical homeostasis |
| cell-cell signaling |
| negative regulation of molecular function |
| regulation of immune response |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| mitochondrion |
| negative regulation of RNA metabolic process |
| cell cycle |
| negative regulation of cell communication |
| negative regulation of signaling |
| ion transport |
| nervous system process |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| generation of neurons |
| peptide transport |
| positive regulation of transcription, DNA-templated |
| response to oxygen-containing compound |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cell development |
| regulation of immune system process |
| intracellular signal transduction |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of cell differentiation |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12715
- Expression level (log2 read counts): 5.39
Expression Distribution
PPP3CA Expression in NALM6 Cells: 5.39
