RMI1

Entrez Summary: N/A
UniProt Summary: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. {ECO:0000269|PubMed:15775963, ECO:0000269|PubMed:16537486, ECO:0000269|PubMed:16595695}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ML-792 0.2μM R08 exp505	-2.36
Cidofovir 10μM R07 exp345	-1.99
RO-3306 3 to 4μM on day4 R04 exp165	-1.89
BI-2536 0.02μM R03 exp96	-1.82
∆-9-Tetrahydrocannabinol 30μM R08 exp445	1.7
Rucaparib 6.5μM R08 exp520	1.73
Resveratrol 16μM R03 exp147	1.75
Aphidicolin 0.4μM R08 exp440	1.82
Thimerosal 0.85μM R08 exp529	1.82
Pterostilbene 16μM R02 exp78	2.02
VE-822 0.04μM R06 exp300	2.03
Olaparib 4μM R08 exp512	2.09
Hydroxyurea 100μM R07 exp329	2.19
Mitomycin-C 0.06μM R08 exp503	4.44
Diepoxybutane 3μM R07 exp354	6.88
Nutlin-3A 1.6μM R06 exp294	7.95
Talazoparib 0.006μM R06 exp299	8.25

Global Fraction of Cell Lines Where Essential: 149/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	5/28
blood	6/28
bone	7/26
breast	12/33
central nervous system	6/56
cervix	1/4
colorectal	5/17
esophagus	1/13
fibroblast	0/1
gastric	4/16
kidney	7/21
liver	3/20
lung	11/75
lymphocyte	2/16
ovary	5/26
pancreas	4/24
peripheral nervous system	3/16
plasma cell	2/15
prostate	0/1
skin	3/24
soft tissue	3/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	6/29
uterus	3/5

Expression Distribution

RecQ helicase-Topo III complex
reduction of food intake in response to dietary excess
resolution of meiotic recombination intermediates
meiotic chromosome separation
response to dietary excess
eating behavior
chromosome separation
reciprocal meiotic recombination
homologous recombination
nucleotide binding
multicellular organism growth
feeding behavior
meiotic chromosome segregation
double-strand break repair via homologous recombination
recombinational repair
meiosis I
meiosis I cell cycle process
response to glucose
response to hexose
response to monosaccharide
meiotic nuclear division
meiotic cell cycle process
response to carbohydrate
double-strand break repair
regulation of signal transduction by p53 class mediator
glucose homeostasis
carbohydrate homeostasis
DNA replication
nuclear chromosome segregation
DNA recombination
meiotic cell cycle
chromosome segregation
nuclear body
nuclear division
organelle fission
developmental growth
growth
response to nutrient levels
DNA repair
response to extracellular stimulus