SEC63

Entrez Summary: The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008].
UniProt Summary: Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cerivastatin 0.15μM R05 exp226	-2.98
Golgicide-A 4μM R03 exp122	-2.54
Bortezomib 0.005μM R00 exp6	-2.46
Fluvastatin 2.2μM R06 exp282	-2.28
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.03
THZ531 0.11μM R07 exp409	-1.89
SB202190 10μM R03 exp148	-1.73
THZ531 0.11 to 0.125μM on day4 R07 exp410	-1.73
BVD-523 15μM R02 exp67	1.73
Etoposide 0.1μM R05 exp198	1.76
Amiloride 100μM R08 exp447	1.78
Rotenone 2μM R00 exp33	1.78
Deguelin 0.15μM R05 exp209	1.81
UM0129480 7μM R02 exp85	1.82
DABN racemic mixture R03 exp93	1.85
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.94
SNS-032 15μM R08 exp443	1.95
LY2090314 0.003μM R08 exp500 no dilution day6	1.97
2-Deoxy-D-glucose 800μM R05 exp214	1.98
LLY-283 2.6μM R06 exp290	2
Thimerosal 0.85μM R08 exp529	2.05
Hippuristanol 0.12μM R08 exp488	2.24
42°C R08 exp539	2.33
UMK57 1μM R01 exp59	2.39
UM131593 0.2μM R03 exp106	2.46
Rotenone 20μM R00 exp34	2.69
GSK-J4 1-1.25μM to day4 R07 exp363	2.81
Mdivi-1 15μM R05 exp217	2.98
Arsenate 40μM R06 exp264	3.55

Global Fraction of Cell Lines Where Essential: 37/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	2/28
bone	0/26
breast	2/33
central nervous system	2/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	2/16
kidney	0/21
liver	1/20
lung	3/75
lymphocyte	0/16
ovary	1/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	4/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	1/29
uterus	1/5

Expression Distribution

Sec63
DnaJ

Sec62/Sec63 complex
posttranslational protein targeting to membrane, translocation
posttranslational protein targeting to endoplasmic reticulum membrane
multicellular organism aging
intracellular protein transmembrane transport
protein transmembrane transport
SRP-dependent cotranslational protein targeting to membrane
cotranslational protein targeting to membrane
protein targeting to ER
establishment of protein localization to endoplasmic reticulum
liver development
hepaticobiliary system development
protein localization to endoplasmic reticulum
protein targeting to membrane
signaling receptor activity
establishment of protein localization to membrane
aging
protein targeting
gland development
establishment of protein localization to organelle
protein localization to membrane
protein localization to organelle
endoplasmic reticulum membrane
intracellular protein transport
endoplasmic reticulum
transmembrane transport
RNA binding
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
membrane