SPCS3

Entrez Summary: N/A
UniProt Summary: Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. {ECO:0000269|PubMed:27499293}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 338/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	15/28
blood	10/28
bone	15/26
breast	13/33
central nervous system	37/56
cervix	2/4
colorectal	10/17
esophagus	3/13
fibroblast	0/1
gastric	11/16
kidney	9/21
liver	10/20
lung	33/75
lymphocyte	7/16
ovary	8/26
pancreas	6/24
peripheral nervous system	6/16
plasma cell	6/15
prostate	1/1
skin	15/24
soft tissue	3/9
thyroid	1/2
upper aerodigestive	6/22
urinary tract	14/29
uterus	1/5

Expression Distribution

Screen	Score
Rotenone 2μM R00 exp33	1.74
Rotenone 20μM R00 exp34	1.94

signal peptidase complex
signal peptide processing
peptidase activity
protein targeting to ER
establishment of protein localization to endoplasmic reticulum
protein localization to endoplasmic reticulum
protein processing
protein maturation
protein targeting
establishment of protein localization to organelle
peptide metabolic process
protein localization to organelle
cellular amide metabolic process
endoplasmic reticulum membrane
intracellular protein transport
endoplasmic reticulum
proteolysis
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
gene expression