SPR

Entrez Summary: This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the final one or two reductions in tetra- hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hydroxyurea 100μM R07 exp329	-3.14
Tubacin 1.6μM R07 exp416	-2.95
Rifampicin 30μM R08 exp430	-2.27
Docosahexaenoic-acid 50μM R07 exp356	-2.07
IU1-47 25μM R04 exp182	-2.05
Epigallocatechin gallate 20μM R05 exp230	-1.91
MKC9989 10μM R03 exp133	-1.89
Resveratrol 16μM R03 exp147	-1.89
proTAME 5μM R04 exp187	-1.85
THZ531 0.225μM R08 exp444	-1.83
Isonicotinamide 500μM R03 exp129	-1.81
Bisphenol F 50μM R08 exp457	-1.8
Rucaparib 6.5μM R08 exp520	-1.79
Olaparib 4μM R08 exp512	-1.75
BI-2536 0.02μM R03 exp96	1.71
Pimelic-diphenylamide-106 5μM R00 exp28	1.72
Myriocin 25μM R06 exp293	1.76
Vinblastine 0.2μM R03 exp108	1.76
Amiloride 100μM R08 exp447	1.77
Monensin 0.3μM R08 exp507	1.82
VER-155008 3.9μM R06 exp301	1.84
Methotrexate 0.01μM R08 exp501	1.85

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sepiapterin reductase activity
tetrahydrobiopterin metabolic process
tetrahydrobiopterin biosynthetic process
aldo-keto reductase (NADP) activity
nitric oxide biosynthetic process
pteridine-containing compound biosynthetic process
nitric oxide metabolic process
diol biosynthetic process
reactive nitrogen species metabolic process
diol metabolic process
reactive oxygen species biosynthetic process
pteridine-containing compound metabolic process
NADP binding
neurotransmitter biosynthetic process
regulation of nitric-oxide synthase activity
regulation of monooxygenase activity
polyol biosynthetic process
neurotransmitter metabolic process
regulation of oxidoreductase activity
polyol metabolic process
reactive oxygen species metabolic process
alcohol biosynthetic process
coenzyme biosynthetic process
organic hydroxy compound biosynthetic process
cofactor biosynthetic process
coenzyme metabolic process
alcohol metabolic process
regulation of neurotransmitter levels
cofactor metabolic process
organic hydroxy compound metabolic process
drug metabolic process
small molecule biosynthetic process
oxidation-reduction process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
small molecule metabolic process