SRPRB

Entrez Summary: N/A
UniProt Summary: Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Amiloride 100μM R08 exp447	-2.12
Disulfiram 4.3μM R06 exp281	-1.82
Ammonium tetrathiomolybdate 10μM R08 exp448	1.74
TRAIL 50ng/ml R00 exp36	1.86
Mitomycin-C 0.06μM R08 exp503	1.91
TRAIL 5ng/ml R00 exp35	1.98
Salinomycin 3.5μM R08 exp521	2.09
Actinomycin-D 0.01μM R00 exp4	2.43

Global Fraction of Cell Lines Where Essential: 12/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	1/16
ovary	1/26
pancreas	2/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cytoplasmic microtubule
IRE1-mediated unfolded protein response
endoplasmic reticulum unfolded protein response
cellular response to unfolded protein
cellular response to topologically incorrect protein
response to unfolded protein
response to topologically incorrect protein
response to endoplasmic reticulum stress
GTP binding
endoplasmic reticulum membrane
cellular response to stress
membrane