WDR82

Entrez Summary: N/A
UniProt Summary: Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. {ECO:0000269|PubMed:17998332, ECO:0000269|PubMed:18838538, ECO:0000269|PubMed:20516061}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tubastatin-A 2.5μM R07 exp417	-2.43
Lapatinib 5μM R01 exp47	-2.31
BI-6727 0.001μM R01 exp42	-2.2
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-2.1
CR131-b 0.005μM R08 exp474	-2.02
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-1.97
Tenofovir 10μM R07 exp405	-1.88
Erlotinib 10μM R05 exp216	-1.86
S-trityl-L-cysteine 0.5μM R05 exp243	-1.72
TRAIL 50ng/ml R00 exp36	-1.71
Salubrinal 20μM R07 exp399	-1.7
BI-2536 0.02μM R03 exp96	1.71
Vinblastine 0.2μM R03 exp108	1.71
Deferoxamine 11μM R07 exp350	1.79
Cannabidiol 20μM R08 exp466	1.84
SNS-032 15μM R08 exp443	1.87
Doxorubicin 0.02μM R08 exp478	2.01
Milciclib 2μM R08 exp502	2.08
GSK-J4 1.5μM R08 exp441	2.26
Salinomycin 3.5μM R08 exp521	2.28
Aphidicolin 0.4μM R08 exp440	2.53
BI-6727 0.04μM R03 exp98	2.61
SB743921 0.001μM R05 exp244	2.74
JQ1 0.8μM R08 exp435	2.8
Vinblastine 0.015μM R05 exp208	3.02
Etoposide 0.3μM R05 exp199	3.14

Global Fraction of Cell Lines Where Essential: 721/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	25/25
breast	32/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	14/15
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	14/14
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	7/7
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

PTW/PP1 phosphatase complex
Set1C/COMPASS complex
histone H3-K4 trimethylation
histone methyltransferase activity (H3-K4 specific)
peptidyl-lysine trimethylation
histone H3-K4 methylation
histone methyltransferase complex
histone lysine methylation
peptidyl-lysine methylation
histone methylation
nuclear chromosome, telomeric region
chromatin
protein alkylation
protein methylation
macromolecule methylation
methylation
peptidyl-lysine modification
histone modification
covalent chromatin modification
chromatin binding
chromatin organization
nucleolus
peptidyl-amino acid modification
chromosome organization