ZNF592

Entrez Summary: This gene is thought to play a role in a complex developmental pathway and the regulation of genes involved in cerebellar development. Mutations in this gene have been associated with autosomal recessive spinocerebellar ataxia. [provided by RefSeq, Jan 2011].
UniProt Summary: May be involved in transcriptional regulation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK-J5 1.5μM R08 exp484	-1.74
Atovaquone 15μM R08 exp451	1.72
CI-1040 9.5μM R08 exp472	1.72
Nutlin-3A 1.6μM R06 exp294	1.73
Colchicine 0.009μM R05 exp215	1.76
Talazoparib 0.006μM R06 exp299	1.77
PU-H71 1μM R08 exp515	1.78
BI-2536 0.02μM R03 exp96	1.79
Cerivastatin 0.15μM R05 exp226	1.8
Staurosporine 0.02μM R08 exp524	1.81
Mdivi-1 15μM R05 exp217	1.86
Dorsomorphin 5μM R07 exp357	1.89
Actinomycin-D 0.001μM R00 exp3	1.94
SNS-032 15μM R08 exp443	1.97
TRAIL 50ng/ml R00 exp36	2.02
Demecolcine 0.03μM R05 exp228	2.1
Centrinone 0.5μM R07 exp343	2.13
Quercetin 20μM R08 exp517	2.17
CB-5083 0.4μM R08 exp468	2.23
Doxorubicin 0.02μM R08 exp478	2.25
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	2.29
UMK57 1μM R01 exp59	2.33
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	2.34
Deferoxamine 11μM R07 exp350	2.35
RO-3307 4.7μM R02 exp80	2.4
3-Bromopyruvate 7μM R04 exp175	2.42
Docosahexaenoic-acid 50μM R07 exp356	2.5
Aphidicolin 0.4μM R08 exp440	2.73
ML-792 0.2μM R08 exp505	2.95
UM131593 0.2μM R03 exp106	3.13
BML-284 0.09μM R08 exp460	3.75

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific