PBXIP1

Gene Information

Official Symbol: PBXIP1
Official Name: PBX homeobox interacting protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 57326
UniProt: Q96AQ6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. {ECO:0000269|PubMed:10825160, ECO:0000269|PubMed:12360403, ECO:0000269|PubMed:17043237}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MLN-4924 2μM R00 exp22	-2.12
Quercetin 20μM R08 exp517	-2.07
Etoposide 0.3μM R05 exp199	-2.06
TIC10 10μM R08 exp532	-1.94
Monensin 0.3μM R08 exp507	-1.85
Hippuristanol 0.12μM R08 exp488	-1.83
Aphidicolin 0.4μM R08 exp440	-1.8
THZ1 0.06μM R08 exp531	-1.71
Nifurtimox 1μM R03 exp141	1.81
Pterostilbene 16μM R02 exp78	1.86

Gene	Correlation
TWISTNB	0.482
TBC1D3C	0.479
TBC1D3G	0.475
TBC1D3	0.466
TBC1D3H	0.464
RPS7	0.458
CHD4	0.456
CHMP2A	0.455
TP53TG3	0.455
TP53TG3B	0.455
TP53TG3C	0.454
PSMA6	0.453
TBC1D3K	0.451
TBC1D3L	0.451
TBC1D3E	0.451
TBC1D3I	0.45
COL2A1	0.443
NOL10	0.443
DDTL	0.441
TBC1D3F	0.44
SUPT5H	0.44
MED17	0.433
STIL	0.431
VASN	0.431
PWP2	0.43
DNTTIP2	0.43
TIMELESS	0.428
CBWD3	0.425
POLR2J3	0.423
PRIM1	0.423
SUPT6H	0.422
LRR1	0.422
SLC6A17	0.419
DDX56	0.419
NPIPB8	0.419
RAD51	0.418
C14orf93	0.414
RRP15	0.412
LAD1	0.412
UPF1	0.412
SLC38A7	0.41
PSMD2	0.409
C1QTNF9B	0.409
TCEB3CL2	0.409
PAN2	0.408
MYB	0.407
CBWD5	0.406
SLC4A1	0.405
PSMB2	0.405
OGFR	0.404
TP53TG3D	0.403
DTL	0.402
COPE	0.401
MYO18A	0.401
MFRP	0.401
PSMD3	0.4

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2130
Expression level (log2 read counts): 6.01

Expression Distribution