PI4KB
Gene Information
- Official Symbol: PI4KB
- Official Name: phosphatidylinositol 4-kinase beta
- Aliases and Previous Symbols: N/A
- Entrez ID: 5298
- UniProt: Q9UBF8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| PI3 PI4 kinase |
GO Terms
| 1-phosphatidylinositol 4-kinase activity |
| rough endoplasmic reticulum membrane |
| 14-3-3 protein binding |
| phosphatidylinositol phosphorylation |
| lipid phosphorylation |
| phosphatidylinositol-mediated signaling |
| inositol lipid-mediated signaling |
| phosphatidylinositol biosynthetic process |
| mitochondrial outer membrane |
| phosphatidylinositol metabolic process |
| lipid modification |
| glycerophospholipid biosynthetic process |
| glycerolipid biosynthetic process |
| receptor-mediated endocytosis |
| phospholipid biosynthetic process |
| endosome |
| glycerophospholipid metabolic process |
| phospholipid metabolic process |
| glycerolipid metabolic process |
| organophosphate biosynthetic process |
| endocytosis |
| lipid biosynthetic process |
| Golgi membrane |
| import into cell |
| perinuclear region of cytoplasm |
| organophosphate metabolic process |
| cellular lipid metabolic process |
| lipid metabolic process |
| phosphorylation |
| ATP binding |
| intracellular signal transduction |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 10/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 2/28 |
| bone | 1/26 |
| breast | 0/33 |
| central nervous system | 2/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 2/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1601
- Expression level (log2 read counts): 5.98
Expression Distribution
PI4KB Expression in NALM6 Cells: 5.98
