Table of Contents

Monensin 0.3μM R08 exp507

Mechanism of Action

Polyether antibiotic, binds monovalent cations, Na+/H+ antiporter, blocks Golgi transport

Technical Notes

Compound References

  • PubChem Name: Monensin sodium
  • Synonyms: Monensin A sodium salt
  • CAS #: 22373-78-0
  • PubChem CID: 23667299
  • IUPAC: sodium;(2S,3R,4S)-4-[(2S,5R,7S,8R,9S)-2-[(2R,5S)-5-ethyl-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]oxolan-2-yl]-7-hydroxy-2,8-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]-3-methoxy-2-methylpentanoate
  • INCHI Name: InChI=1S/C36H62O11.Na/c1-10-34(31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28)12-11-27(44-34)33(8)13-14-35(47-33)17-25(38)22(5)30(45-35)23(6)29(42-9)24(7)32(39)40;/h19-31,37-38,41H,10-18H2,1-9H3,(H,39,40);/q;+1/p-1/t19-,20-,21+,22+,23-,24-,25-,26+,27+,28-,29+,30-,31+,33-,34-,35+,36-;/m0./s1
  • INCHI Key: XOIQMTLWECTKJL-FBZUZRIGSA-M
  • Molecular Weight: 692.9
  • Canonical SMILES: CCC1(CCC(O1)C2(CCC3(O2)CC(C(C(O3)C(C)C(C(C)C(=O)[O-])OC)C)O)C)C4C(CC(O4)C5C(CC(C(O5)(CO)O)C)C)C.[Na+]
  • Isomeric SMILES: CC[C@]1(CC[C@@H](O1)[C@@]2(CC[C@@]3(O2)C[C@@H]([C@H]([C@H](O3)[C@@H](C)[C@H]([C@H](C)C(=O)[O-])OC)C)O)C)[C@H]4[C@H](C[C@@H](O4)[C@@H]5[C@H](C[C@H]([C@@](O5)(CO)O)C)C)C.[Na+]
  • Molecular Formula: C36H61NaO11

Compound Supplier

  • Supplier Name: Med Chem Express
  • Catalog #: HY-N0150
  • Lot #: 28765

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M+Na)+ Calcd for C36H62O11 693.41843; found 693.41958

Dose Response Curve

  • Platform ID: Monensin
  • Min: -4.4012; Max: 96.4158





IC Concentration (µM)
IC10 N/A
IC20 0.0433
IC30 0.0965
IC40 0.1929
IC50 0.3731
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
19/5ScoresViewViewViewViewView