ELP6

Entrez Summary: N/A
UniProt Summary: Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Erlotinib 10μM R05 exp216	-1.91
Prochlorperazine 5.2μM R02 exp77	-1.74
Isonicotinamide 500μM R03 exp129	-1.73
Senexin-A 25μM R07 exp400	1.74
Phenformin 20μM R03 exp143	1.86
Bisphenol A 100μM R06 exp269	1.88
Doxorubicin 0.02μM R08 exp478	1.9
Citral 75μM R06 exp275	1.97
IWR1 50μM R08 exp495	1.99
Monensin 0.3μM R08 exp507	1.99
Rotenone 0.07μM R08 exp431	2.04
Latrunculin-B 10μM R07 exp374	2.17
iCRT14 30μM R08 exp492	2.27
Thapsigargin 0.005μM R07 exp407	2.38
2-Deoxy-D-glucose 800μM R05 exp214	2.45
UM0129480 7μM R02 exp85	2.58
Artemisinin 50μM R08 exp450	2.98
MS023 2μM R03 exp134	3
CR131-b 0.005μM R08 exp474	3.06
MS023 7μM R03 exp135	3.66
Hippuristanol 0.12μM R08 exp488	4.1
Hippuristanol 0.12μM R08 exp489 no dilution day6	4.37

Global Fraction of Cell Lines Where Essential: 631/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	22/28
blood	23/28
bone	21/26
breast	21/33
central nervous system	50/56
cervix	4/4
colorectal	13/17
esophagus	13/13
fibroblast	1/1
gastric	14/16
kidney	20/21
liver	19/20
lung	62/75
lymphocyte	10/16
ovary	23/26
pancreas	21/24
peripheral nervous system	13/16
plasma cell	8/15
prostate	1/1
skin	22/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	28/29
uterus	4/5

Expression Distribution