TACC3

Entrez Summary: N/A
UniProt Summary: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UMK57 0.6μM R03 exp107	-4.25
Taxol 0.004μM R03 exp103	-3.81
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-3.48
Demecolcine 0.03μM R05 exp228	-3.48
Colchicine 0.009μM R05 exp215	-3.4
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-3.25
Taxol 0.002μM R01 exp54	-2.96
Mdivi-1 15μM R05 exp217	-2.93
BML-284 0.09μM R08 exp460	-2.91
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-2.83
Docetaxel 0.002μM R01 exp45	-2.61
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-2.58
Cabazitaxel 0.001μM R05 exp223	-2.5
Quercetin 20μM R08 exp517	-2.5
UMK57 1μM R01 exp59	-2.41
UM131593 0.1μM R01 exp58	-2.38
Epothilone-B 0.0015μM R05 exp231	-2.32
Sulforaphane 9μM R08 exp525	-2.28
Vincristine 0.0005μM R04 exp190	-2.27
HMS-I1 1μM R01 exp46	-2.19
Sulforaphane 9μM R08 exp526 no dilution day6	-2.13
2-Methoxyestradiol 0.55μM R07 exp310	-2.11
UM131593 0.2μM R03 exp106	-1.99
S-trityl-L-cysteine 0.5μM R05 exp243	-1.98
Thimerosal 0.85μM R08 exp529	-1.89

Global Fraction of Cell Lines Where Essential: 77/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	0/28
bone	2/26
breast	3/33
central nervous system	6/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	2/16
kidney	2/21
liver	1/20
lung	6/75
lymphocyte	2/16
ovary	6/26
pancreas	3/24
peripheral nervous system	2/16
plasma cell	0/15
prostate	1/1
skin	2/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	9/22
urinary tract	4/29
uterus	2/5

Expression Distribution