Table of Contents

BI-D1870 2μM R04 exp162

Mechanism of Action

Inhibits ribosomal p90 S6 Kinase, active against RSK1/2/3/4 isoforms

Technical Notes

Protein References

  • PubChem Name: 2-((3,5-Difluoro-4-hydroxyphenyl)amino)-8-isopentyl-5,7-dimethyl-7,8-dihydropteridin-6(5H)-one
  • Synonyms: N/A
  • CAS #: 501437-28-1
  • PubChem CID: 25023738
  • IUPAC: 2-(3,5-difluoro-4-hydroxyanilino)-5,7-dimethyl-8-(3-methylbutyl)-7H-pteridin-6-one
  • INCHI Name: InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24)
  • INCHI Key: DTEKTGDVSARYDS-UHFFFAOYSA-N
  • Molecular Weight: 391.4
  • Canonical SMILES: CC1C(=O)N(C2=CN=C(N=C2N1CCC(C)C)NC3=CC(=C(C(=C3)F)O)F)C
  • Isomeric SMILES: N/A
  • Molecular Formula: C19H23F2N5O2

Protein Supplier

  • Supplier Name: Selleck Chemicals
  • Catalog #: S2843
  • Lot #: N/A

Protein Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C19H23F2N5O2 392.18926; found 392.19055

Dose Response Curve

  • Platform ID: BI-D1870
  • Min: -18.9777; Max: 94.2694





IC Concentration (µM)
IC10 N/A
IC20 2.5715
IC30 2.6985
IC40 2.8073
IC50 2.9110
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
15/0ScoresViewViewViewViewView