Table of Contents

Hydroxychloroquine 30μM R08 exp490

Mechanism of Action

Lysosomotropic agent, prevents sequestration of heme into hemozoin, forms toxic complex with heme, also inhibits TLR 7/9

Technical Notes

Protein References

  • PubChem Name: Hydroxychloroquine sulfate
  • Synonyms: HCQ sulfate
  • CAS #: 747-36-4
  • PubChem CID: 12947
  • IUPAC: 2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol;sulfuric acid
  • INCHI Name: InChI=1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
  • INCHI Key: JCBIVZZPXRZKTI-UHFFFAOYSA-N
  • Molecular Weight: 434
  • Canonical SMILES: CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO.OS(=O)(=O)O
  • Isomeric SMILES: N/A
  • Molecular Formula: C18H28ClN3O5S

Protein Supplier

  • Supplier Name: Combi-Blocks
  • Catalog #: QA-8047
  • Lot #: B11244

Protein Characterization

Characterization data not available.

Dose Response Curve

  • Platform ID: Hydroxychloroquine
  • Min: -11.2129; Max: 98.9777





IC Concentration (µM)
IC10 18.4900
IC20 24.0900
IC30 28.7200
IC40 33.1700
IC50 37.8700
IC60 43.2200
IC70 49.9200
IC80 59.5200
IC90 77.5500


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
9/0ScoresViewViewViewViewView