NR2C2AP

Entrez Summary: N/A
UniProt Summary: May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes. {ECO:0000269|PubMed:12486131}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BML-284 0.09μM R08 exp460	-2.06
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	-1.78
B02 10μM R08 exp453	-1.77
UM0011500 5μM R05 exp245	-1.73
5-Fluorouracil 2μM R00 exp1	-1.72
Pyrazinamide 100μM R08 exp516	-1.71
GSK-J4 1-1.25μM to day4 R07 exp363	1.71
R-DABN 8μM R03 exp111	1.72
UM0131023 0.05μM R05 exp248	1.72
2-Deoxy-D-glucose 800μM R05 exp214	1.76
Lead acetate 2000μM R08 exp498 no dilution day6	1.79
Ibrutinib 10μM R08 exp442	1.8
Oligomycin-A 2μM R00 exp25	1.8
Trimetrexate 0.03μM R08 exp535	1.83
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.86
Citral 75μM R06 exp275	1.88
Bisphenol A 100μM R06 exp269	1.91
ETC-159 50μM R08 exp480	1.93
Mubritinib 0.2μM R01 exp48	2
Hippuristanol 0.12μM R08 exp488	2.03
QNZ 0.01μM R08 exp439	2.09
Citral 50μM R06 exp274	2.21
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	2.21
Radicicol 0.16μM R05 exp242	2.28
IWR1 50μM R08 exp495	2.32
Lead acetate 2000μM R08 exp497	2.37
Q15 1 to 2μM on day4 R04 exp164	2.39
Mubritinib 0.2μM R02 exp65	2.51
Chloramphenicol 20μM R00 exp13	2.71
MS023 7μM R03 exp135	2.94
MS023 2μM R03 exp134	4.27

Global Fraction of Cell Lines Where Essential: 74/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	5/28
blood	0/28
bone	6/26
breast	4/33
central nervous system	9/56
cervix	0/4
colorectal	1/17
esophagus	1/13
fibroblast	0/1
gastric	1/16
kidney	2/21
liver	5/20
lung	6/75
lymphocyte	0/16
ovary	3/26
pancreas	0/24
peripheral nervous system	3/16
plasma cell	0/15
prostate	0/1
skin	3/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	5/29
uterus	0/5

Expression Distribution

transcription initiation from RNA polymerase II promoter
DNA-templated transcription, initiation
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression