ODC1

Gene Information

Official Symbol: ODC1
Official Name: ornithine decarboxylase 1
Aliases and Previous Symbols: N/A
Entrez ID: 4953
UniProt: P11926
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013].
UniProt Summary: Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. {ECO:0000269|PubMed:17900240}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Chloroquine 32μM R08 exp470	-4.41
Hydroxychloroquine 30μM R08 exp490	-4.41
Trientine 500μM R08 exp534	-2.99
L-74142 5μM R03 exp131	-2.77
Geldanamycin 0.01μM R05 exp235	-2.51
A-366 10μM R03 exp115	-2.41
PNU96415E 10μM R03 exp145	-2.23
Cycloheximide 0.2μM R00 exp15	-2.15
Glyphosate 1000μM R06 exp283	-2.11
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	-1.98
Thioridazine 5μM R08 exp530	-1.97
EPZ-5676 30μM R05 exp233	-1.95
Wortmannin 5μM R00 exp38	-1.9
PF-06409577 20μM R07 exp389	-1.88
Isoniazid 100μM R08 exp494	-1.87
UM0130462 0.025 to 0.035μM day4 R05 exp247	-1.75
A-196 10μM R03 exp114	-1.72
Celastrol 0.12μM R05 exp225	-1.7
Docetaxel 0.002μM R01 exp45	1.7
PU-H71 1μM R08 exp515	1.71
Arsenic trioxide 60μM R08 exp449	1.73
Latrunculin-B 10μM R07 exp374	1.73
Nifuroxazide 1μM R01 exp51	1.74
LLY-283 2.6μM R06 exp290	1.87
Nocodazole 0.1μM R03 exp94	1.88
Vinblastine 0.2μM R03 exp108	1.89
I-BRD9 4μM R07 exp365	1.9
Sulforaphane 9μM R08 exp525	1.9
UM131593 0.2μM R03 exp106	1.92
GSK461364A 0.1μM R03 exp126	1.93
Nifuroxazide 5μM R03 exp102	1.93
Artemisinin 50μM R08 exp450	1.94
Deferoxamine 11μM R07 exp350	1.95
Taxol 0.004μM R03 exp103	2
TIC10 10μM R08 exp532	2
Quercetin 20μM R08 exp517	2.02
BI-2536 0.02μM R03 exp96	2.03
LY2090314 0.003μM R08 exp500 no dilution day6	2.03
BI-2536 0.0042μM R03 exp95	2.08
Sulforaphane 9μM R08 exp526 no dilution day6	2.08
CFI-400945 25μM R08 exp469	2.1
Golgicide-A 4μM R03 exp122	2.1
Thimerosal 0.85μM R08 exp529	2.1
Rucaparib 6.5μM R08 exp520	2.11
QNZ 0.01μM R05 exp241	2.16
Bortezomib 0.005μM R00 exp6	2.17
Milciclib 2μM R08 exp502	2.17
Atovaquone 15μM R08 exp451	2.18
MK2206 4μM R08 exp504	2.23
Vinblastine 0.002μM R01 exp60	2.32
Aminopterin 0.005μM R07 exp335	2.33
BI-6727 0.0125μM R03 exp97	2.45
JQ1 0.8μM R08 exp435	2.46
Bisphenol S 100μM R08 exp458	2.63
MLN-4924 0.2μM R00 exp21	2.73
LY2090314 0.003μM R08 exp499	2.98
Arsenate 40μM R06 exp264	3.26
Tubacin 1.6μM R07 exp416	3.36
Methotrexate 0.01μM R08 exp501	3.52
ML-792 0.2μM R08 exp505	3.55
Centrinone 0.5μM R07 exp343	3.59

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7976
Expression level (log2 read counts): 9.16

Expression Distribution

Gene	Correlation
AZIN1	0.477
SRM	0.437
VPS35	0.412

Orn Arg deC N
Orn DAP Arg deC

ornithine decarboxylase activity
putrescine biosynthetic process from ornithine
putrescine biosynthetic process
putrescine metabolic process
ornithine metabolic process
polyamine biosynthetic process
polyamine metabolic process
cellular biogenic amine biosynthetic process
amine biosynthetic process
cellular biogenic amine metabolic process
cellular amine metabolic process
regulation of cellular amino acid metabolic process
amine metabolic process
regulation of cellular amine metabolic process
regulation of cellular ketone metabolic process
ammonium ion metabolic process
alpha-amino acid metabolic process
kidney development
response to virus
renal system development
cellular amino acid metabolic process
urogenital system development
regulation of protein catabolic process
regulation of small molecule metabolic process
cellular component
perinuclear region of cytoplasm
protein homodimerization activity
carboxylic acid metabolic process
positive regulation of cell population proliferation
regulation of catabolic process
oxoacid metabolic process
organic acid metabolic process
response to other organism
response to external biotic stimulus
response to biotic stimulus
organonitrogen compound biosynthetic process
regulation of cell population proliferation
cellular nitrogen compound biosynthetic process
small molecule metabolic process