MKC9989 10μM R03 exp133 [The Human Chemical-Genetic Interaction Map Project]

Inhibits IRE1, prevents ER unfolded protein response

Class / Subclass 1: Proteostasis / Unfolded Protein Response Inhibitor
Class / Subclass 2: Signal Transduction / Kinase Inhibitor

Compound References

PubChem Name: 7-Hydroxy-6-methoxy-3-[2-(2-methoxyethoxy)ethyl]-4-methyl-2-oxochromene-8-carbaldehyde
Synonyms: N/A
CAS #: 1338934-20-5
PubChem CID: 89542001
IUPAC: 7-hydroxy-6-methoxy-3-[2-(2-methoxyethoxy)ethyl]-4-methyl-2-oxochromene-8-carbaldehyde
INCHI Name: InChI=1S/C17H20O7/c1-10-11(4-5-23-7-6-21-2)17(20)24-16-12(10)8-14(22-3)15(19)13(16)9-18/h8-9,19H,4-7H2,1-3H3
INCHI Key: QSVDQIXSUDHAOF-UHFFFAOYSA-N
Molecular Weight: 336.3
Canonical SMILES: CC1=C(C(=O)OC2=C(C(=C(C=C12)OC)O)C=O)CCOCCOC
Isomeric SMILES: N/A
Molecular Formula: C17H20O7

Compound Supplier

Supplier Name: Med Chem Express
Catalog #: HY-12399
Lot #: N/A

Compound Characterization

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C17H20O7 337.12818; found 337.12666

Dose Response Curve

Platform ID: MKC4500-B-03
Min: -6.3858; Max: 13.1219

IC	Concentration (µM)
IC10	N/A
IC20	N/A
IC30	N/A
IC40	N/A
IC50	N/A
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 03
Dose: 10µM
Days of incubation: 8
Doublings: 7.4
Numbers of reads: 11690289

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
0/0	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
GCLC	-2.78	0.07
GCLM	-2.76	0.06
GSS	-2.69	0.06
GSTM5	-2.51	0.22
TRIM7	-2.40	0.31
SEPSECS	-2.33	0.49
SARS	-2.24	0.83
LRP8	-2.23	0.31
NUP93	-2.23	0.63
RPL36A-HNRNPH2	-2.19	0.83
NDUFS5	-2.17	0.63
GFM2	-2.16	0.49
NUPR1	-2.16	0.49
KDSR	-2.15	0.42
CNIH2	-2.11	0.52
ENO1	-2.09	0.63
ELOVL1	-2.08	0.49
POLI	-2.07	0.81
UROS	-2.03	0.49
DOK5	-2.01	0.63
SLC25A26	-1.99	0.63
OR56A4	-1.99	0.52
PCDHB12	-1.98	0.52
RENBP	-1.93	0.63
FES	-1.91	0.63
TMEM126B	-1.91	0.63
WWC3	-1.90	0.63
SPR	-1.89	0.63
RPE	-1.88	0.64
TMEM150C	-1.88	0.63
XAB2	1.93	0.82
MCM7	1.93	0.68
CALU	1.94	0.62
ADH1A	1.94	0.62
MAU2	1.95	0.71
COPZ1	1.95	0.66
FZD6	1.95	0.62
NOM1	1.95	0.64
EXOSC5	1.98	0.62
ZFP14	1.99	0.62
TRAF3IP3	2.00	0.62
OR51Q1	2.00	0.64
TCEAL2	2.01	0.62
AFP	2.04	0.62
FAM109B	2.07	0.64
TFRC	2.09	0.80
USP11	2.09	0.62
BIRC5	2.11	0.66
EIF3J	2.11	0.66
RPL38	2.13	0.64
MED19	2.13	0.64
NFS1	2.14	0.66
NEGR1	2.23	0.62
PES1	2.25	0.64
GOT1	2.27	0.38
MMP16	2.27	0.38
CORO6	2.47	0.38
RBM7	2.58	0.38
SART1	2.84	0.66
POLA1	3.00	0.62

GO Term	Fold Change	Genes
nonribosomal peptide biosynthetic process	126.88	GCLC,GCLM,GSS
acid-amino acid ligase activity	84.59	GCLC,GCLM,GSS
glutathione metabolic process	45.55	GCLC,GCLM,GSS,GSTM5

Last modified: 2026/01/15 21:36
by 127.0.0.1