DABN 2μM R00 exp16 [The Human Chemical-Genetic Interaction Map Project]

Unknown

Class / Subclass 1: Uncharacterized Mechanism / Chemical Screen Hit

Compound References

PubChem Name: [1,1'-Binaphthalene]-2,2'-diamine
Synonyms: N/A
CAS #: 4488-22-6
PubChem CID: 20571
IUPAC: 1-(2-aminonaphthalen-1-yl)naphthalen-2-amine
INCHI Name: InChI=1S/C20H16N2/c21-17-11-9-13-5-1-3-7-15(13)19(17)20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12H,21-22H2
INCHI Key: DDAPSNKEOHDLKB-UHFFFAOYSA-N
Molecular Weight: 284.4
Canonical SMILES: C1=CC=C2C(=C1)C=CC(=C2C3=C(C=CC4=CC=CC=C43)N)N
Isomeric SMILES: N/A
Molecular Formula: C20H16N2

Compound Supplier

Supplier Name: Chem-Impex International
Catalog #: 24623
Lot #: 001702-20140303

Compound Characterization

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C20H16N2 285.13862; found 285.13894

Dose Response Curve

Platform ID: DABN
Min: -10.2228; Max: 85.8979

IC	Concentration (µM)
IC10	N/A
IC20	6.0249
IC30	6.1377
IC40	6.2318
IC50	6.3193
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 00
Dose: 2µM
Days of incubation: 8
Doublings: 6.4
Numbers of reads: 10428304

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
1/1	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
ASB3	-2.86	0.05
ORC3	-2.50	0.42
CEPT1	-2.45	0.24
SENP6	-2.39	0.24
TRPM4	-2.36	0.42
DCAF15	-2.28	0.43
COX8C	-2.18	0.43
PARL	-2.15	0.43
LMLN	-2.11	0.43
OR4F4	-2.08	0.43
NUDT5	-2.08	0.43
VAC14	-2.05	0.43
RAB11FIP3	-2.03	0.43
DPAGT1	-2.03	0.43
TXNL4B	-2.02	0.43
COX4I1	-2.01	0.43
NKX6-2	-1.98	0.43
CRELD1	-1.98	0.64
SPRN	-1.97	0.43
ZMYND19	-1.97	0.43
ZNHIT1	-1.96	0.43
PGGT1B	-1.95	0.43
SCFD1	-1.94	0.65
KIAA1432	-1.92	0.46
ZIC2	-1.92	0.46
CHMP1A	-1.89	0.64
FARS2	-1.88	0.66
KRT6B	-1.88	0.54
TXNL4A	-1.86	0.73
RFC5	-1.86	0.58
RPS28	2.13	0.52
RUVBL1	2.13	0.52
MYO1H	2.13	0.33
PIGW	2.15	0.30
WEE1	2.15	0.48
GPR156	2.17	0.26
LECT1	2.18	0.26
CNTNAP2	2.21	0.26
RFC1	2.25	0.50
C19orf53	2.26	0.30
ZNF675	2.28	0.26
ADAM18	2.28	0.30
PNPLA8	2.30	0.30
MYCBP2	2.30	0.26
ECD	2.31	0.30
PSMA1	2.37	0.39
TPX2	2.39	0.39
NUP188	2.41	0.26
NPIPB3	2.46	0.43
PLEKHA4	2.48	0.17
RPL14	2.56	0.33
SPATA12	2.57	0.07
NUP93	2.58	0.33
CEP76	2.63	0.06
CALCOCO2	2.66	0.06
CKAP5	2.82	0.33
SMU1	2.92	0.26
ANXA5	2.94	0.03
RPS13	3.04	0.08
NDC80	3.12	0.26

Screen	Correlation	Plot
Rifampicin 10μM R00 exp32	0.07	View
Nicotinamide 1000μM R03 exp101	0.057	View
Wortmannin 0.5μM R00 exp37	0.055	View
Rapamycin 1μM R00 exp29	0.052	View
5-Fluorouracil 2μM R00 exp1	0.068	View
CCCP 1μM R00 exp11	0.063	View
Cycloheximide 0.02μM R00 exp14	0.062	View

Last modified: 2026/01/15 21:36
by 127.0.0.1