BI-D1870 2μM R04 exp162
Mechanism of Action
Inhibits ribosomal p90 S6 Kinase, active against RSK1/2/3/4 isoforms
- Class / Subclass 1: Signal Transduction / Kinase Inhibitor
Technical Notes
Compound References
- PubChem Name: 2-((3,5-Difluoro-4-hydroxyphenyl)amino)-8-isopentyl-5,7-dimethyl-7,8-dihydropteridin-6(5H)-one
- Synonyms: N/A
- CAS #: 501437-28-1
- PubChem CID: 25023738
- IUPAC: 2-(3,5-difluoro-4-hydroxyanilino)-5,7-dimethyl-8-(3-methylbutyl)-7H-pteridin-6-one
- INCHI Name: InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24)
- INCHI Key: DTEKTGDVSARYDS-UHFFFAOYSA-N
- Molecular Weight: 391.4
- Canonical SMILES: CC1C(=O)N(C2=CN=C(N=C2N1CCC(C)C)NC3=CC(=C(C(=C3)F)O)F)C
- Isomeric SMILES: N/A
- Molecular Formula: C19H23F2N5O2
Compound Supplier
- Supplier Name: Selleck Chemicals
- Catalog #: S2843
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C19H23F2N5O2 392.18926; found 392.19055
Dose Response Curve
- Platform ID: BI-D1870
- Min: -18.9777; Max: 94.2694
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 2.5715 |
| IC30 | 2.6985 |
| IC40 | 2.8073 |
| IC50 | 2.9110 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 04
- Dose: 2µM
- Days of incubation: 8
- Doublings: 5.0
- Numbers of reads: 16218675
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 15/0 | Scores |
BI-D1870 2μM R04 exp162
BI-D1870 2μM R04 exp162 vs UMK57 0.6μM R03 exp107
BI-D1870 2μM R04 exp162 vs Epigallocatechin gallate 20μM R05 exp230
BI-D1870 2μM R04 exp162 vs GSK461364A 0.005μM R03 exp125
BI-D1870 2μM R04 exp162 vs Ixabepilone 0.004 to 0.005μM on day4 R04 exp184
BI-D1870 2μM R04 exp162 vs Combretastatin A4 0.002 to 0.003μM day4 R04 exp179
BI-D1870 2μM R04 exp162 vs S-trityl-L-cysteine 0.5μM R05 exp243
BI-D1870 2μM R04 exp162 vs I-BRD9 4μM R07 exp365
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311 vs BI-D1870 2μM R04 exp162
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312 vs BI-D1870 2μM R04 exp162
BI-2536 0.0042μM R03 exp95 vs BI-D1870 2μM R04 exp162
