CCT251545 0.2μM R06 exp271
Mechanism of Action
Inhibits CDK8 and CDK19 mediator-associated kinases
- Class / Subclass 1: Gene Regulation / Transcription Inhibitor
- Class / Subclass 2: Signal Transduction / Kinase Inhibitor
Technical Notes
Compound References
- PubChem Name: 8-{3-Chloro-5-[4-(1-Methyl-1h-Pyrazol-4-Yl)phenyl]pyridin-4-Yl}-2,8-Diazaspiro[4.5]decan-1-One
- Synonyms: N/A
- CAS #: 1661839-45-7
- PubChem CID: 77050682
- IUPAC: 8-[3-chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one
- INCHI Name: InChI=1S/C23H24ClN5O/c1-28-15-18(12-27-28)16-2-4-17(5-3-16)19-13-25-14-20(24)21(19)29-10-7-23(8-11-29)6-9-26-22(23)30/h2-5,12-15H,6-11H2,1H3,(H,26,30)
- INCHI Key: LBFYQISQYCGDDW-UHFFFAOYSA-N
- Molecular Weight: 421.9
- Canonical SMILES: CN1C=C(C=N1)C2=CC=C(C=C2)C3=CN=CC(=C3N4CCC5(CCNC5=O)CC4)Cl
- Isomeric SMILES: N/A
- Molecular Formula: C23H24ClN5O
Compound Supplier
- Supplier Name: Cayman Chemical
- Catalog #: 18761
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C23H24ClN5O 422.17421; found 422.1743
Dose Response Curve
- Platform ID: CCT251545
- Min: -8.9474; Max: 38.9173
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 06
- Dose: 200nM
- Days of incubation: 8
- Doublings: 6.9
- Numbers of reads: 9191896
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 1/1 | Scores |
CCT251545 0.2μM R06 exp271
CCT251545 0.2μM R06 exp271 vs UM0011500 5μM R05 exp245
ABT-702 5μM R07 exp318 vs CCT251545 0.2μM R06 exp271
