VHL-ligand-1 20μM R07 exp421

Mechanism of Action

Binds VHL, targeting moiety for PROTACs

  • Class / Subclass 1: Proteostasis / Bivalent Ligand

Technical Notes

Compound References

  • PubChem Name: Protein degrader 1 hydrochloride
  • Synonyms: N/A
  • CAS #: 1448189-80-7
  • PubChem CID: 118864076
  • IUPAC: (2S,4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide;hydrochloride
  • INCHI Name: InChI=1S/C22H30N4O3S.ClH/c1-13-18(30-12-25-13)15-7-5-14(6-8-15)10-24-20(28)17-9-16(27)11-26(17)21(29)19(23)22(2,3)4;/h5-8,12,16-17,19,27H,9-11,23H2,1-4H3,(H,24,28);1H/t16-,17+,19-;/m1./s1
  • INCHI Key: JYRTWGCWUBURGU-MSSRUXLCSA-N
  • Molecular Weight: 467
  • Canonical SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)N)O.Cl
  • Isomeric SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)N)O.Cl
  • Molecular Formula: C22H31ClN4O3S

Compound Supplier

  • Supplier Name: Cayman Chemical
  • Catalog #: 21591
  • Lot #: 0505579-1

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C22 H30 N4 O3 S 431.21114; found 431.21176

Dose Response Curve

  • Platform ID: VHL_Ligand_1
  • Min: -13.9762; Max: 12.9391





IC Concentration (µM)
IC10 N/A
IC20 N/A
IC30 N/A
IC40 N/A
IC50 N/A
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

  • Round: 07
  • Dose: 20µM
  • Days of incubation: 8
  • Doublings: 7.0
  • Numbers of reads: 18199347

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
0/0ScoresViewViewViewViewView

  • Last modified: 2026/01/15 21:36
  • by 127.0.0.1