Zebularine 20μM R07 exp423
Mechanism of Action
Inhibits cytidine deaminase, transition state analog, also inhibits DNMT1 via reversible covalent complex
- Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor
Technical Notes
Compound References
- PubChem Name: Zebularine
- Synonyms: NSC309132; 4-Deoxyuridine
- CAS #: 3690-10-6
- PubChem CID: 100016
- IUPAC: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
- INCHI Name: InChI=1S/C9H12N2O5/c12-4-5-6(13)7(14)8(16-5)11-3-1-2-10-9(11)15/h1-3,5-8,12-14H,4H2/t5-,6-,7-,8-/m1/s1
- INCHI Key: RPQZTTQVRYEKCR-WCTZXXKLSA-N
- Molecular Weight: 228.2
- Canonical SMILES: C1=CN(C(=O)N=C1)C2C(C(C(O2)CO)O)O
- Isomeric SMILES: C1=CN(C(=O)N=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O
- Molecular Formula: C9H12N2O5
Compound Supplier
- Supplier Name: Ark Pharm Inc.
- Catalog #: AK326160
- Lot #: WG0156999-170316001
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+Na)+ Calcd for C9H12N2O5 251.06384; found 251.06358
Dose Response Curve
- Platform ID: Zebularine
- Min: -22.6878; Max: 11.3745
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 07
- Dose: 20µM
- Days of incubation: 8
- Doublings: 6.3
- Numbers of reads: 17023526
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 3/3 | Scores |
Zebularine 20μM R07 exp423
