Arsenic trioxide 60μM R08 exp449
Mechanism of Action
Induces degradation of aberrant PML-RAR‘± fusion protein in acute promyelocytic leukemia
- Class / Subclass 1: Environmental Stresses / Heavy Metal
- Class / Subclass 2: Signal Transduction / Apoptosis Inducer
Technical Notes
Compound References
- PubChem Name: 2,4,6,8,9,10-Hexaoxa-1,3,5,7-tetraarsatricyclo[3.3.1.13,7]decane
- Synonyms: N/A
- CAS #: 1327-53-3
- PubChem CID: 518605
- IUPAC: 2,4,6,8,9,10-hexaoxa-1,3,5,7-tetrarsatricyclo[3.3.1.13,7]decane
- INCHI Name: InChI=1S/As4O6/c5-1-6-3-8-2(5)9-4(7-1)10-3
- INCHI Key: KTTMEOWBIWLMSE-UHFFFAOYSA-N
- Molecular Weight: 395.68
- Canonical SMILES: O1[As]2O[As]3O[As]1O[As](O2)O3
- Isomeric SMILES: N/A
- Molecular Formula: As4O6
Compound Supplier
- Supplier Name: Toronto Research Chemicals
- Catalog #: A774130
- Lot #: 14-CGS-186-1
Compound Characterization
- XRPD: Expected As2O3; found As2O3
Dose Response Curve
- Platform ID: Arsenic_Oxide
- Min: 14.1313; Max: 99.7631
| IC | Concentration (µM) |
|---|---|
| IC10 | 30.7900 |
| IC20 | 46.5800 |
| IC30 | 61.3300 |
| IC40 | 76.8500 |
| IC50 | 94.5200 |
| IC60 | 116.3000 |
| IC70 | 145.7000 |
| IC80 | 191.8000 |
| IC90 | 290.2000 |
Screen Summary
- Round: 08
- Dose: 60µM
- Days of incubation: 8
- Doublings: 4.5
- Numbers of reads: 16171461
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 2/8 | Scores |
Arsenic trioxide 60μM R08 exp449
Arsenic trioxide 60μM R08 exp449 vs Thimerosal 0.85μM R08 exp529
Arsenic trioxide 60μM R08 exp449 vs Rapamycin 10μM R00 exp30
Arsenic trioxide 60μM R08 exp449 vs Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307
