Dihydrosphingosine 8μM R08 exp476 [The Human Chemical-Genetic Interaction Map Project]

Inhibits cytosolic phospholipase A2α (cPLA2α) activity

Class / Subclass 1: Metabolism / Metabolite

Compound References

PubChem Name: Sphinganine
Synonyms: N/A
CAS #: 764-22-7
PubChem CID: 91486
IUPAC: (2S,3R)-2-aminooctadecane-1,3-diol
INCHI Name: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18+/m0/s1
INCHI Key: OTKJDMGTUTTYMP-ZWKOTPCHSA-N
Molecular Weight: 301.5
Canonical SMILES: CCCCCCCCCCCCCCCC(C(CO)N)O
Isomeric SMILES: CCCCCCCCCCCCCCC[C@H]([C@H](CO)N)O
Molecular Formula: C18H39NO2

Compound Supplier

Supplier Name: Toronto Research Chemicals
Catalog #: D449400
Lot #: 2-UTS-154-1

Compound Characterization

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C18H39NO2 302.30536; found 302.30628

Dose Response Curve

Platform ID: Dihydrosphingosine
Min: -10.6873; Max: 99.7582

IC	Concentration (µM)
IC10	8.3490
IC20	9.1120
IC30	9.6580
IC40	10.1300
IC50	10.5800
IC60	11.0600
IC70	11.5900
IC80	12.2900
IC90	13.4100

Screen Summary

Round: 08
Dose: 8µM
Days of incubation: 8
Doublings: 6.8
Numbers of reads: 18647851

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
2/1	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
SGPL1	-5.02	<0.01
PDXK	-4.45	<0.01
CCDC101	-2.64	0.05
NAA10	-2.51	0.28
RAB11A	-2.38	0.28
PACS1	-2.29	0.42
R3HCC1	-2.27	0.42
DPAGT1	-2.24	0.41
CCDC67	-2.22	0.28
NPTN	-2.22	0.28
SNF8	-2.18	0.42
ARL1	-2.14	0.38
MS4A13	-2.13	0.83
PPP1CA	-2.09	0.41
AVIL	-2.08	0.44
SNRPD3	-2.08	0.86
KCTD2	-2.06	0.42
UHRF1	-2.04	0.61
FAM207A	-2.02	0.42
KIF2A	-2.01	0.42
C7orf65	-1.99	0.43
SARS	-1.98	0.87
DOPEY1	-1.98	0.43
ABCA13	-1.95	0.56
RTCB	-1.94	0.75
ACSL4	-1.94	0.56
ENO1	-1.93	0.75
KLHL32	-1.93	0.50
DHX36	-1.91	0.61
FOXF2	-1.90	0.62
TKTL1	1.97	0.54
PABPC4	1.98	0.54
RPS19	1.98	0.76
NUDT11	2.00	0.54
NUP88	2.01	0.55
NLRP2	2.02	0.59
ZC3H3	2.03	0.54
SP8	2.04	0.54
C11orf63	2.06	0.43
KIAA0947	2.06	0.54
S100A2	2.07	0.43
YIPF4	2.11	0.43
ZBED2	2.13	0.67
ANKRD40	2.13	0.57
FZD6	2.15	0.39
OR4D11	2.16	0.39
DDX46	2.17	0.77
POLE2	2.17	0.67
UTP11L	2.20	0.39
DYNC1H1	2.21	0.75
EIF6	2.23	0.66
WDR66	2.26	0.59
EXOSC3	2.29	0.39
CDC45	2.34	0.59
RNPC3	2.35	0.39
PSMC4	2.45	0.39
PNO1	2.76	0.43
FIP1L1	2.78	0.11
PCDHB11	2.89	0.04
RPA1	3.17	0.54

Last modified: 2026/01/15 21:36
by 127.0.0.1