ADRM1

Gene Information

Official Symbol: ADRM1
Official Name: adhesion regulating molecule 1
Aliases and Previous Symbols: N/A
Entrez ID: 11047
UniProt: Q16186
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
UniProt Summary: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex. {ECO:0000269|PubMed:16815440, ECO:0000269|PubMed:16906146, ECO:0000269|PubMed:16990800, ECO:0000269|PubMed:17139257, ECO:0000269|PubMed:18497817, ECO:0000269|PubMed:24752541, ECO:0000269|PubMed:25702870, ECO:0000269|PubMed:25702872}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Milciclib 2μM R08 exp502	-2.52
HMS-I1 10μM R06 exp256	-2.35
Nutlin-3A 1.6μM R06 exp294	-2.23
CB-5083 0.4μM R08 exp468	-2.1
iCRT14 30μM R08 exp492	-2.02
42°C R08 exp539	-1.84
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.84
Etoposide 1μM R00 exp19	-1.75
Thapsigargin 0.005μM R07 exp407	-1.73
MLN-4924 2μM R00 exp22	-1.72
Mdivi-1 15μM R05 exp217	-1.7
TRAIL 5ng/ml R00 exp35	1.81
A-769662 20μM R07 exp331	1.85

Gene	Correlation
RPS16	0.51
RPS3A	0.478
PSMA6	0.476
PSMD11	0.466
ZFAND5	0.464
GOLGA6L1	0.462
SMG7	0.458
RPL8	0.451
DDX56	0.451
PSMD1	0.45
VASN	0.446
C19orf53	0.444
PAF1	0.443
RPS3	0.44
PSMB4	0.44
HGC6.3	0.435
HAP1	0.434
PSMC2	0.433
RPS19	0.426
RPSA	0.425
RPS11	0.424
BCL2L1	0.422
IK	0.422
WDR43	0.419
PAN3	0.418
RPS14	0.418
RPL14	0.415
PSMC1	0.414
POLE	0.413
CCNA2	0.41
RPL18	0.41
RPS5	0.409
RPS7	0.409
NOP16	0.404
PAN2	0.404
TBC1D3	0.404
PSMA7	0.403
TCEB3CL2	0.403
CKAP5	0.403
RPS12	0.403
BYSL	0.402
TERF2	0.402
PSMC6	0.401
ZNF106	0.4

Global Fraction of Cell Lines Where Essential: 28/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	0/28
bone	0/25
breast	3/33
central nervous system	2/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	2/21
liver	0/20
lung	1/75
lymphocyte	1/14
ovary	1/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	1/7
thyroid	0/2
upper aerodigestive	1/22
urinary tract	3/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1541
Expression level (log2 read counts): 5.89

Expression Distribution

endopeptidase activator activity
proteasome regulatory particle, lid subcomplex
proteasome assembly
proteasome binding
proteasome complex
transcription elongation from RNA polymerase II promoter
ubiquitin binding
DNA-templated transcription, elongation
protease binding
positive regulation of endopeptidase activity
positive regulation of peptidase activity
protein deubiquitination
protein modification by small protein removal
positive regulation of proteolysis
regulation of endopeptidase activity
regulation of peptidase activity
transcription by RNA polymerase II
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
protein catabolic process
regulation of proteolysis
positive regulation of hydrolase activity
cellular protein-containing complex assembly
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
macromolecule catabolic process
organonitrogen compound catabolic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
proteolysis
regulation of hydrolase activity
organic cyclic compound biosynthetic process
positive regulation of catalytic activity