ASUN

Gene Information

Official Symbol: INTS13
Official Name: integrator complex subunit 13
Aliases and Previous Symbols: N/A
Entrez ID: 55726
UniProt: Q9NVM9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing (PubMed:23904267). {ECO:0000269|PubMed:15737938, ECO:0000269|PubMed:23097494, ECO:0000269|PubMed:23904267, ECO:0000305|PubMed:23097494, ECO:0000305|PubMed:23904267}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
S-trityl-L-cysteine 0.5μM R05 exp243	-2.64
Tubacin 1.6μM R07 exp416	-2.32
Rapamycin 10μM R00 exp30	-2.3
2-Deoxy-D-glucose 800μM R05 exp214	-2.09
Dynasore 7μM R08 exp436	-2.04
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-1.94
GSK591 2.6μM R03 exp128	-1.94
Methotrexate 0.01μM R08 exp501	-1.89
Aminopterin 0.005μM R07 exp335	-1.87
Rapamycin 1μM R00 exp29	-1.84
CAY10603 0.55μM R08 exp467	-1.82
MK-1775 0.32μM R02 exp75	-1.82
Doxorubicin 0.02μM R08 exp478	1.72
TIC10 10μM R08 exp532	1.74
6-Thio-2-deoxyguanosine 2μM R06 exp259	1.76
5-Azacytidine 2μM R07 exp330	1.78
Chloramphenicol 20μM R00 exp13	1.86
NMS-873 0.07μM R07 exp380	1.89
QNZ 0.01μM R08 exp439	1.97
Monensin 0.3μM R08 exp507	2.02
Mubritinib 0.2μM R02 exp65	2.04
CR131-b 0.005μM R08 exp474	2.07
Ammonium tetrathiomolybdate 10μM R08 exp448	2.11
Rucaparib 6.5μM R08 exp520	2.21
BVD-523 15μM R02 exp67	2.23
iCRT14 30μM R08 exp492	2.26
Oligomycin-A 2μM R00 exp25	2.3
Cerivastatin 0.15μM R05 exp226	2.35
Nicotine 3000μM R08 exp510	2.36
CB-5083 0.4μM R08 exp468	2.43
UM0129480 7μM R02 exp85	2.45
Rotenone 0.07μM R08 exp431	2.54
AICAR 240μM R05 exp211	2.65
Aphidicolin 0.4μM R08 exp440	2.66
Atovaquone 15μM R08 exp451	2.7
Trientine 500μM R08 exp534	2.85
TRAIL 50ng/ml R00 exp36	2.95
MS023 2μM R03 exp134	2.96
Nutlin-3A 1.6μM R06 exp294	2.97
MS023 7μM R03 exp135	3.07
Mubritinib 0.2μM R01 exp48	3.2
AICAR 240μM R03 exp116	3.26
TRAIL 5ng/ml R00 exp35	3.27
MLN-4924 0.2μM R00 exp21	3.55
Latrunculin-B 10μM R07 exp374	3.74
Trimetrexate 0.03μM R08 exp535	3.84
Fluvastatin 2.2μM R06 exp282	4.01

Global Fraction of Cell Lines Where Essential: 7/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2425
Expression level (log2 read counts): 5.9

Expression Distribution

Gene	Correlation
INTS10	0.843
C7orf26	0.819
VWA9	0.602
URM1	0.479
MOCS3	0.471
CTU1	0.455
ELP3	0.405
ACSL3	0.403
UBA5	0.401
MLST8	0.4

protein localization to nuclear envelope
regulation of fertilization
centrosome localization
microtubule organizing center localization
snRNA transcription by RNA polymerase II
snRNA transcription
flagellated sperm motility
sperm motility
mitotic spindle organization
cilium-dependent cell motility
ncRNA transcription
cilium or flagellum-dependent cell motility
microtubule cytoskeleton organization involved in mitosis
spindle organization
regulation of reproductive process
protein localization to nucleus
microtubule cytoskeleton organization
transcription by RNA polymerase II
cell division
organelle localization
mitotic cell cycle process
regulation of mitotic cell cycle
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
microtubule-based process
mitotic cell cycle
protein localization to organelle
regulation of multi-organism process
cell cycle process
cell motility
localization of cell
nucleobase-containing compound biosynthetic process
cytoskeleton organization
heterocycle biosynthetic process
aromatic compound biosynthetic process
regulation of cell cycle
organic cyclic compound biosynthetic process
locomotion
cell cycle