FAM98B

Entrez Summary: N/A
UniProt Summary: Positively stimulates PRMT1-induced protein arginine dimethylated arginine methylation (PubMed:28040436). Promotes colorectal cancer cell malignancy (PubMed:28040436). {ECO:0000269|PubMed:28040436}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	-1.96
DKK1 89ng/ml R08 exp477	-1.94
Ribavirin 10μM R01 exp52	-1.7
UM0131023 0.05μM R05 exp248	1.7
Rucaparib 6.5μM R08 exp520	1.73
Monensin 0.3μM R08 exp507	1.74
BI-6727 0.04μM R03 exp98	1.76
YM155 0.001μM R08 exp432	1.76
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.78
Hydroxyurea 100μM R07 exp329	1.8
Hippuristanol 0.12μM R08 exp488	1.81
BI-2536 0.02μM R03 exp96	1.83
Rotenone 0.07μM R08 exp431	1.83
∆-9-Tetrahydrocannabinol 30μM R08 exp445	1.85
Deguelin 0.15μM R05 exp209	1.87
5-Fluorouracil 20μM R00 exp2	1.91
Sulforaphane 9μM R08 exp525	2.06
Vemurafenib 6.6μM R08 exp434	2.11
Q15 1 to 2μM on day4 R04 exp164	2.13
Etoposide 1μM R00 exp19	2.14
Arsenate 40μM R06 exp264	2.17
Cryptotanshinone 12μM R05 exp227	2.22
Quinacrine 2.5μM R03 exp146	2.22
NMS-873 0.07μM R07 exp380	2.26
Salubrinal 20μM R07 exp399	2.27
Benzoate 10000μM R08 exp455	2.28
Cannabidiol 13μM R08 exp465	2.29
Clomiphene 4.4μM R02 exp68	2.3
2-Deoxy-D-glucose 800μM R05 exp214	2.41
ABT-702 5μM plus CoCl2 18μM R07 exp320	2.44
Thimerosal 0.85μM R08 exp529	2.57
CB-5083 0.4μM R08 exp468	2.67
Bisphenol A 100μM R06 exp269	3.99

Global Fraction of Cell Lines Where Essential: 22/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	1/28
bone	0/26
breast	2/33
central nervous system	1/56
cervix	0/4
colorectal	1/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	2/21
liver	0/20
lung	6/75
lymphocyte	1/16
ovary	1/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	1/5

Expression Distribution

tRNA-splicing ligase complex
protein methyltransferase activity
tRNA splicing, via endonucleolytic cleavage and ligation
RNA splicing, via endonucleolytic cleavage and ligation
tRNA processing
protein methylation
protein alkylation
tRNA metabolic process
macromolecule methylation
methylation
ncRNA processing
RNA splicing
ncRNA metabolic process
intracellular membrane-bounded organelle
RNA processing
positive regulation of cell population proliferation
identical protein binding
RNA binding
regulation of cell population proliferation
RNA metabolic process
positive regulation of gene expression
gene expression