GID8

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
3-Bromopyruvate 7μM R04 exp175	-2.76
Cryptotanshinone 12μM R05 exp227	-2.63
FK-506 30μM R07 exp359	-2.56
Demecolcine 0.03μM R05 exp228	-2.5
Milciclib 2μM R08 exp502	-2.37
Bortezomib 0.005μM R00 exp6	-2.32
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-2.25
JQ1 0.8μM R08 exp435	-2.25
Rotenone 20μM R00 exp34	-2.22
Palbociclib 1μM R07 exp382	-2.18
Hydroxyurea 100μM R07 exp329	-2.16
5-Azacytidine 2μM R07 exp330	-2.14
MK-1775 0.32μM R02 exp75	-2.12
WYE-354 6μM R02 exp90	-1.97
Thimerosal 0.85μM R08 exp529	-1.83
Resveratrol 16μM R03 exp147	-1.82
IU1-C 25μM R04 exp183	-1.8
ABT-702 5μM plus CoCl2 18μM R07 exp320	-1.77
2-Methoxyestradiol 0.55μM R07 exp310	-1.76
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.7
Pyridostatin 4μM R05 exp240	1.71
Chloroquine 32μM R08 exp470	1.82
Fluvastatin 2.2μM R06 exp282	2.03
FTY720 3μM R08 exp483	2.08
Dimethyloxaloylglycine 100μM R05 exp229	2.13
Azithromycin 100μM R08 exp452	2.32
Rapamycin 1μM R00 exp29	2.61
Arsenate 40μM R06 exp264	2.62
Rapamycin 2μM R07 exp306	2.88
Rapamycin 10μM R00 exp30	3.15
AICAR 240μM R03 exp116	3.24
Rapamycin 0.001μM R08 exp429	3.66
GSK626616 14μM R08 exp485	4.19

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

LisH
RanBPM CRA

ubiquitin ligase complex
positive regulation of canonical Wnt signaling pathway
positive regulation of Wnt signaling pathway
regulation of canonical Wnt signaling pathway
cell-cell signaling by wnt
Wnt signaling pathway
regulation of Wnt signaling pathway
cell surface receptor signaling pathway involved in cell-cell signaling
cell junction
protein homodimerization activity
positive regulation of cell population proliferation
cell-cell signaling
regulation of cell population proliferation
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling