HK2
Gene Information
- Official Symbol: HK2
- Official Name: hexokinase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 3099
- UniProt: P52789
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Hexokinase 2 |
| Hexokinase 1 |
GO Terms
| hexokinase activity |
| mannokinase activity |
| glucokinase activity |
| maintenance of protein location in mitochondrion |
| fructokinase activity |
| negative regulation of mitochondrial membrane permeability |
| negative regulation of membrane permeability |
| glucose binding |
| positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization |
| regulation of autophagy of mitochondrion in response to mitochondrial depolarization |
| positive regulation of autophagy of mitochondrion |
| response to mitochondrial depolarisation |
| glucose 6-phosphate metabolic process |
| carbohydrate phosphorylation |
| glucose catabolic process to pyruvate |
| canonical glycolysis |
| NADH regeneration |
| glycolytic process through fructose-6-phosphate |
| glycolytic process through glucose-6-phosphate |
| glucose catabolic process |
| NADH metabolic process |
| maintenance of protein localization in organelle |
| glycolytic process |
| regulation of autophagy of mitochondrion |
| ATP generation from ADP |
| sarcoplasmic reticulum |
| lactation |
| NAD metabolic process |
| response to ischemia |
| ADP metabolic process |
| hexose catabolic process |
| negative regulation of reactive oxygen species metabolic process |
| regulation of glucose import |
| apoptotic mitochondrial changes |
| nucleoside diphosphate phosphorylation |
| purine nucleoside diphosphate metabolic process |
| monosaccharide catabolic process |
| nucleotide phosphorylation |
| purine ribonucleoside diphosphate metabolic process |
| ribonucleoside diphosphate metabolic process |
| establishment of protein localization to mitochondrion |
| pyruvate metabolic process |
| regulation of mitochondrial membrane permeability |
| regulation of glucose transmembrane transport |
| body fluid secretion |
| maintenance of protein location in cell |
| protein localization to mitochondrion |
| regulation of membrane permeability |
| nucleoside diphosphate metabolic process |
| cellular glucose homeostasis |
| maintenance of location in cell |
| cellular response to leukemia inhibitory factor |
| response to leukemia inhibitory factor |
| maintenance of protein location |
| glucose metabolic process |
| positive regulation of mitochondrion organization |
| carbohydrate catabolic process |
| positive regulation of autophagy |
| mitochondrial membrane organization |
| mammary gland development |
| hexose metabolic process |
| mitochondrial outer membrane |
| maintenance of location |
| positive regulation of angiogenesis |
| cellular carbohydrate metabolic process |
| regulation of reactive oxygen species metabolic process |
| regulation of mitochondrion organization |
| positive regulation of vasculature development |
| glucose homeostasis |
| carbohydrate homeostasis |
| monosaccharide metabolic process |
| ATP metabolic process |
| mitochondrial transport |
| regulation of angiogenesis |
| purine ribonucleotide metabolic process |
| regulation of vasculature development |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| regulation of autophagy |
| ribose phosphate metabolic process |
| response to hypoxia |
| response to decreased oxygen levels |
| positive regulation of cellular catabolic process |
| purine-containing compound metabolic process |
| response to oxygen levels |
| gland development |
| generation of precursor metabolites and energy |
| positive regulation of catabolic process |
| establishment of protein localization to organelle |
| small molecule catabolic process |
| mitochondrion organization |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| carbohydrate metabolic process |
| regulation of body fluid levels |
| monocarboxylic acid metabolic process |
| nucleobase-containing small molecule metabolic process |
| regulation of transmembrane transport |
| positive regulation of organelle organization |
| protein localization to organelle |
| cellular chemical homeostasis |
| regulation of cellular catabolic process |
| membrane organization |
| organophosphate metabolic process |
| cellular homeostasis |
| carboxylic acid metabolic process |
| apoptotic process |
| oxidation-reduction process |
| regulation of catabolic process |
| oxoacid metabolic process |
| cellular response to cytokine stimulus |
| organic acid metabolic process |
| carbohydrate derivative metabolic process |
| programmed cell death |
| regulation of anatomical structure morphogenesis |
| cell death |
| response to cytokine |
| chemical homeostasis |
| secretion |
| response to abiotic stimulus |
| positive regulation of cellular component organization |
| phosphorylation |
| regulation of organelle organization |
| positive regulation of developmental process |
| ATP binding |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| homeostatic process |
| cellular response to stress |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| organic substance catabolic process |
| regulation of transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 1/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 315
- Expression level (log2 read counts): 7.26
Expression Distribution
HK2 Expression in NALM6 Cells: 7.26
