INTS5

Entrez Summary: N/A
UniProt Summary: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). {ECO:0000269|PubMed:23904267, ECO:0000305|PubMed:16239144}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CFI-400945 25μM R08 exp469	-2.25
DABN 20μM R00 exp17	-2.11
Rotenone 20μM R00 exp34	-1.92
Atovaquone 15μM R08 exp451	-1.85
Etoposide 1μM R00 exp19	-1.84
Ammonium tetrathiomolybdate 10μM R08 exp448	-1.74
Geldanamycin 0.01μM R05 exp235	1.7
Mubritinib 0.2μM R02 exp65	1.71
Nifuroxazide 1μM R01 exp51	1.82
LB-100 2μM R05 exp210	1.85
GSK-J4 1μM R07 exp362	1.91
Celastrol 0.12μM R05 exp225	1.95
Dinaciclib 0.007μM R07 exp355	1.97
BI-2536 0.001μM R01 exp41	1.99
BRD2 inhibitor II 20μM R07 exp341	1.99
proTAME 5μM R04 exp187	2.01
CB-839 10μM R05 exp224	2.02

Global Fraction of Cell Lines Where Essential: 579/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	20/28
blood	25/28
bone	19/26
breast	27/33
central nervous system	41/56
cervix	2/4
colorectal	13/17
esophagus	6/13
fibroblast	1/1
gastric	9/16
kidney	14/21
liver	15/20
lung	60/75
lymphocyte	14/16
ovary	23/26
pancreas	18/24
peripheral nervous system	15/16
plasma cell	12/15
prostate	1/1
skin	22/24
soft tissue	6/9
thyroid	0/2
upper aerodigestive	19/22
urinary tract	24/29
uterus	4/5

Expression Distribution

integrator complex
snRNA 3-end processing
snRNA processing
snRNA metabolic process
ncRNA 3-end processing
snRNA transcription by RNA polymerase II
snRNA transcription
ncRNA transcription
RNA 3-end processing
nuclear membrane
ncRNA processing
ncRNA metabolic process
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
RNA processing
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
membrane
gene expression