KIF18B

Entrez Summary: N/A
UniProt Summary: In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules. {ECO:0000269|PubMed:20600703, ECO:0000269|PubMed:21820309}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Taxol 0.004μM R03 exp103	-5.38
S-trityl-L-cysteine 0.5μM R05 exp243	-5.37
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-4.56
Epothilone-B 0.0015μM R05 exp231	-4.26
Docetaxel 0.002μM R01 exp45	-3.67
Taxol 0.002μM R01 exp54	-2.82
Cabazitaxel 0.001μM R05 exp223	-2.78
Centrinone 0.5μM R07 exp343	-2.39
Chlorpromazine 10μM R07 exp344	-2.36
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-2.13
2-Methoxyestradiol 0.55μM R07 exp310	2.48
Quercetin 20μM R08 exp517	2.8
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	2.89
HMS-I1 1μM R01 exp46	3.13
BML-284 0.09μM R08 exp460	3.29
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	4.37
UM131593 0.2μM R03 exp106	7.08
UMK57 1μM R01 exp59	7.13
Mdivi-1 15μM R05 exp217	7.96

Global Fraction of Cell Lines Where Essential: 84/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	1/28
bone	4/26
breast	1/33
central nervous system	15/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	8/21
liver	2/20
lung	4/75
lymphocyte	1/16
ovary	3/26
pancreas	0/24
peripheral nervous system	2/16
plasma cell	2/15
prostate	0/1
skin	4/24
soft tissue	2/9
thyroid	1/2
upper aerodigestive	5/22
urinary tract	5/29
uterus	1/5

Expression Distribution

microtubule end
astral microtubule
mitotic spindle astral microtubule
mitotic spindle midzone
microtubule depolymerization
microtubule plus-end
ATP-dependent microtubule motor activity, plus-end-directed
protein depolymerization
kinesin binding
motor activity
microtubule polymerization or depolymerization
kinesin complex
microtubule motor activity
mitotic sister chromatid segregation
cellular protein complex disassembly
sister chromatid segregation
mitotic nuclear division
regulation of cell division
nuclear chromosome segregation
ATPase activity
microtubule binding
protein-containing complex disassembly
microtubule-based movement
chromosome segregation
nuclear body
nuclear division
organelle fission
microtubule
cellular component disassembly
supramolecular fiber organization
microtubule cytoskeleton organization
cell division
mitotic cell cycle process
microtubule-based process
mitotic cell cycle
cell cycle process
chromosome organization
cytoskeleton organization
cell cycle
ATP binding