MRPL1
Gene Information
- Official Symbol: MRPL1
- Official Name: mitochondrial ribosomal protein L1
- Aliases and Previous Symbols: N/A
- Entrez ID: 65008
- UniProt: Q9BYD6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Ribosomal L1 |
| MRL1 |
GO Terms
| maturation of LSU-rRNA |
| cytosolic large ribosomal subunit |
| ribosomal large subunit biogenesis |
| mitochondrial translational elongation |
| mitochondrial translational termination |
| translational termination |
| mitochondrial translation |
| translational elongation |
| cellular protein complex disassembly |
| mitochondrial gene expression |
| structural constituent of ribosome |
| rRNA processing |
| rRNA metabolic process |
| protein-containing complex disassembly |
| ribosome biogenesis |
| translation |
| ncRNA processing |
| mitochondrial inner membrane |
| cellular component disassembly |
| peptide biosynthetic process |
| ribonucleoprotein complex biogenesis |
| ncRNA metabolic process |
| amide biosynthetic process |
| peptide metabolic process |
| cellular amide metabolic process |
| RNA processing |
| mitochondrion |
| RNA binding |
| organonitrogen compound biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| protein-containing complex subunit organization |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| FASTKD2 | 0.518 |
| PET112 | 0.493 |
| MRPS21 | 0.488 |
| XPNPEP3 | 0.479 |
| PET117 | 0.477 |
| MTO1 | 0.474 |
| TIMM17A | 0.474 |
| MALSU1 | 0.474 |
| COQ2 | 0.471 |
| RPUSD4 | 0.471 |
| ICT1 | 0.467 |
| COA3 | 0.465 |
| NARS2 | 0.465 |
| CHCHD1 | 0.46 |
| METTL17 | 0.459 |
| QRSL1 | 0.458 |
| NDUFA2 | 0.456 |
| NDUFB10 | 0.454 |
| RBFA | 0.452 |
| MCAT | 0.452 |
| MRPL21 | 0.451 |
| NDUFC1 | 0.448 |
| CARS2 | 0.447 |
| FASTKD5 | 0.446 |
| MRPL45 | 0.445 |
| MRPS6 | 0.445 |
| DAP3 | 0.445 |
| GFM1 | 0.444 |
| MRPL47 | 0.443 |
| RNMTL1 | 0.443 |
| EARS2 | 0.441 |
| MRPS16 | 0.439 |
| SSBP1 | 0.439 |
| FTSJ2 | 0.439 |
| NDUFAF7 | 0.438 |
| NDUFA11 | 0.437 |
| DDX28 | 0.435 |
| MTIF2 | 0.435 |
| GTPBP10 | 0.435 |
| MRPL4 | 0.433 |
| C12orf65 | 0.432 |
| RMND1 | 0.432 |
| RTN4IP1 | 0.431 |
| LRPPRC | 0.429 |
| ACAD9 | 0.428 |
| COA6 | 0.428 |
| MTRF1L | 0.428 |
| NDUFB11 | 0.427 |
| VARS2 | 0.427 |
| MRPS10 | 0.426 |
| NDUFA3 | 0.425 |
| MTG2 | 0.424 |
| CLPP | 0.422 |
| LARS2 | 0.422 |
| COQ4 | 0.422 |
| NDUFC2 | 0.421 |
| COX6A1 | 0.418 |
| SCO2 | 0.415 |
| YARS2 | 0.415 |
| MTERFD2 | 0.415 |
| NDUFAF1 | 0.413 |
| HIGD2A | 0.412 |
| TFB1M | 0.412 |
| NDUFA1 | 0.412 |
| MRPS25 | 0.41 |
| NDUFB2 | 0.41 |
| MRPL53 | 0.408 |
| ECSIT | 0.408 |
| NDUFB4 | 0.406 |
| ERAL1 | 0.405 |
| MRPS27 | 0.402 |
| NDUFAF6 | 0.401 |
| MRPS35 | 0.401 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 5/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 1/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 1/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1957
- Expression level (log2 read counts): 4.3
Expression Distribution
MRPL1 Expression in NALM6 Cells: 4.3
