NDC1
Gene Information
- Official Symbol: NDC1
- Official Name: NDC1 transmembrane nucleoporin
- Aliases and Previous Symbols: N/A
- Entrez ID: 55706
- UniProt: Q9BTX1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Ndc1 Nup |
GO Terms
| nuclear pore transmembrane ring |
| nuclear pore localization |
| nuclear pore distribution |
| nuclear pore complex assembly |
| nuclear pore organization |
| pore complex assembly |
| cellular protein-containing complex localization |
| structural constituent of nuclear pore |
| tRNA-containing ribonucleoprotein complex export from nucleus |
| tRNA export from nucleus |
| tRNA transport |
| ncRNA export from nucleus |
| synapsis |
| intracellular transport of virus |
| host cell |
| transport of virus |
| homologous chromosome segregation |
| chromosome organization involved in meiotic cell cycle |
| protein sumoylation |
| multi-organism localization |
| multi-organism transport |
| nuclear pore |
| regulation of cellular response to heat |
| regulation of glycolytic process |
| localization within membrane |
| regulation of gene silencing by miRNA |
| regulation of carbohydrate catabolic process |
| meiotic chromosome segregation |
| regulation of posttranscriptional gene silencing |
| regulation of gene silencing by RNA |
| mRNA-containing ribonucleoprotein complex export from nucleus |
| mRNA export from nucleus |
| meiosis I |
| meiosis I cell cycle process |
| viral transcription |
| regulation of purine nucleotide metabolic process |
| regulation of nucleotide metabolic process |
| regulation of ATP metabolic process |
| ribonucleoprotein complex export from nucleus |
| ribonucleoprotein complex localization |
| RNA export from nucleus |
| viral gene expression |
| regulation of gene silencing |
| nucleus organization |
| protein export from nucleus |
| meiotic nuclear division |
| mRNA transport |
| regulation of generation of precursor metabolites and energy |
| nuclear export |
| meiotic cell cycle process |
| nuclear envelope |
| RNA transport |
| nucleic acid transport |
| establishment of RNA localization |
| viral life cycle |
| regulation of carbohydrate metabolic process |
| RNA localization |
| actin cytoskeleton |
| nuclear chromosome segregation |
| meiotic cell cycle |
| nuclear membrane |
| nucleobase-containing compound transport |
| protein-containing complex localization |
| nucleocytoplasmic transport |
| nuclear transport |
| chromosome segregation |
| nuclear division |
| organelle fission |
| peptidyl-lysine modification |
| regulation of small molecule metabolic process |
| spermatogenesis |
| male gamete generation |
| gamete generation |
| viral process |
| regulation of cellular response to stress |
| protein modification by small protein conjugation |
| symbiotic process |
| interspecies interaction between organisms |
| multicellular organismal reproductive process |
| sexual reproduction |
| cellular protein-containing complex assembly |
| multicellular organism reproduction |
| peptidyl-amino acid modification |
| protein modification by small protein conjugation or removal |
| regulation of catabolic process |
| multi-organism reproductive process |
| intracellular protein transport |
| cell cycle process |
| chromosome organization |
| cell cycle |
| reproductive process |
| reproduction |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| peptide transport |
| protein-containing complex assembly |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| establishment of protein localization |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| AKIRIN2 | 0.527 |
| SNRPA1 | 0.517 |
| AAAS | 0.51 |
| AHCTF1 | 0.506 |
| ATP13A1 | 0.484 |
| C14orf93 | 0.475 |
| NUP54 | 0.463 |
| TFIP11 | 0.453 |
| NUP85 | 0.453 |
| CDCA3 | 0.447 |
| CKAP5 | 0.444 |
| NUP188 | 0.441 |
| VASN | 0.439 |
| PSMD1 | 0.436 |
| CCDC94 | 0.433 |
| TCEB3CL2 | 0.432 |
| S1PR4 | 0.432 |
| SMG7 | 0.431 |
| EIF4A3 | 0.431 |
| PSMD6 | 0.43 |
| CWC22 | 0.429 |
| C1QTNF9B | 0.428 |
| CDC6 | 0.423 |
| PSMC6 | 0.422 |
| NUFIP2 | 0.421 |
| LRR1 | 0.42 |
| PPFIA4 | 0.42 |
| MYO1H | 0.415 |
| PSMD11 | 0.415 |
| NUP155 | 0.415 |
| TBC1D3G | 0.415 |
| RPS28 | 0.414 |
| BCL2L1 | 0.413 |
| PSMA6 | 0.412 |
| TBC1D3H | 0.412 |
| CNOT1 | 0.411 |
| SMG1 | 0.409 |
| ZFAND5 | 0.409 |
| CDC73 | 0.408 |
| KPNB1 | 0.406 |
| SEL1L | 0.403 |
| SSH2 | 0.402 |
| NUPL1 | 0.4 |
| CBWD3 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 123/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 4/28 |
| blood | 5/28 |
| bone | 3/26 |
| breast | 4/33 |
| central nervous system | 18/56 |
| cervix | 0/4 |
| colorectal | 2/17 |
| esophagus | 1/13 |
| fibroblast | 0/1 |
| gastric | 3/16 |
| kidney | 6/21 |
| liver | 3/20 |
| lung | 13/75 |
| lymphocyte | 2/16 |
| ovary | 6/26 |
| pancreas | 1/24 |
| peripheral nervous system | 5/16 |
| plasma cell | 9/15 |
| prostate | 0/1 |
| skin | 2/24 |
| soft tissue | 2/9 |
| thyroid | 0/2 |
| upper aerodigestive | 3/22 |
| urinary tract | 3/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 875
- Expression level (log2 read counts): 7.37
Expression Distribution
NDC1 Expression in NALM6 Cells: 7.37
