NDUFS3

Entrez Summary: This gene encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase (complex I). Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency.[provided by RefSeq, Apr 2009].
UniProt Summary: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

NADH dehydrogenase activity
substantia nigra development
NADH dehydrogenase (ubiquinone) activity
mitochondrial electron transport, NADH to ubiquinone
mitochondrial respiratory chain complex I
neural nucleus development
NADH dehydrogenase complex assembly
mitochondrial respiratory chain complex I assembly
electron transfer activity
midbrain development
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
negative regulation of intrinsic apoptotic signaling pathway
mitochondrial respiratory chain complex assembly
mitochondrial membrane
respiratory electron transport chain
reactive oxygen species metabolic process
oxidative phosphorylation
regulation of intrinsic apoptotic signaling pathway
cellular respiration
electron transport chain
negative regulation of cell growth
ATP metabolic process
negative regulation of apoptotic signaling pathway
energy derivation by oxidation of organic compounds
negative regulation of growth
nuclear body
mitochondrial matrix
regulation of apoptotic signaling pathway
regulation of cell growth
generation of precursor metabolites and energy
mitochondrion organization
negative regulation of intracellular signal transduction
regulation of growth
brain development
head development
cellular protein-containing complex assembly
negative regulation of apoptotic process
negative regulation of programmed cell death
oxidation-reduction process