PTPMT1

Gene Information

Official Symbol: PTPMT1
Official Name: protein tyrosine phosphatase mitochondrial 1
Aliases and Previous Symbols: N/A
Entrez ID: 114971
UniProt: Q8WUK0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NFN1 0.4μM R03 exp99	-2.15
L-BMAA 500 to 750μM on day4 R04 exp185	-1.77
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.7
Sulforaphane 9μM R08 exp526 no dilution day6	1.7
NMS-873 0.07μM R07 exp380	1.77
Salinomycin 3.5μM R08 exp521	1.77
Ammonium tetrathiomolybdate 10μM R08 exp448	1.79
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.81
Fluvastatin 2.2μM R06 exp282	1.83
5-Azacytidine 2μM R07 exp330	1.84
Olaparib 4μM R08 exp512	1.84
Rapamycin 2μM R07 exp306	1.84
PU-H71 1μM R08 exp515	1.86
Phenformin 20μM R03 exp143	1.87
Thapsigargin 0.005μM R07 exp407	1.9
Centrinone 0.5μM R07 exp343	1.91
Thimerosal 0.85μM R08 exp529	1.93
Atovaquone 15μM R08 exp451	2.02
LJH685 50μM R08 exp433	2.05
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	2.06
VER-155008 3.9μM R06 exp301	2.06
∆-9-Tetrahydrocannabinol 30μM R08 exp445	2.11
ABT-702 5μM plus CoCl2 18μM R07 exp320	2.13
CAY10603 0.55μM R08 exp467	2.15
Talazoparib 0.006μM R06 exp299	2.16
Hippuristanol 0.12μM R08 exp488	2.22
Amiloride 100μM R08 exp447	2.25
Arsenate 40μM R06 exp264	2.26
Doxorubicin 0.02μM R08 exp478	2.28
Trimetrexate 0.03μM R08 exp535	2.29
Staurosporine 0.02μM R08 exp524	2.35
CB-5083 0.4μM R08 exp468	2.41
JQ1 0.8μM R08 exp435	2.43
MS023 7μM R03 exp135	2.43
Mubritinib 0.2μM R01 exp48	2.45
Torin1 0.08μM R02 exp82	2.48
Aphidicolin 0.4μM R08 exp440	2.59
Milciclib 2μM R08 exp502	2.66
Rotenone 0.07μM R08 exp431	2.66
Erlotinib 10μM R05 exp216	2.68
CoCl2 18μM R07 exp346	2.82
QNZ 0.01μM R08 exp439	2.86
MK2206 4μM R08 exp504	2.98
Phenformin 20μM R05 exp212	3.48
LLY-283 2.6μM R06 exp290	4.11

Gene	Correlation
DNLZ	0.64
PGM3	0.545
PMVK	0.538
TRMT61A	0.526
DHRSX	0.514
PGS1	0.507
PARS2	0.486
GATC	0.472
PPCDC	0.467
DAP3	0.461
ROMO1	0.449
NARS2	0.445
TRMT6	0.445
MRPL21	0.44
COQ3	0.438
YARS2	0.433
MRPS35	0.429
G6PD	0.428
LSM10	0.427
RARS2	0.426
FASTKD5	0.421
LARS2	0.417
AARS2	0.416
MRPL23	0.415
EARS2	0.415
TAMM41	0.415
TMEM242	0.414
OPA1	0.413
KIAA0391	0.41
TARS2	0.41
FH	0.404

Global Fraction of Cell Lines Where Essential: 184/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	5/28
blood	6/28
bone	12/26
breast	7/33
central nervous system	21/56
cervix	1/4
colorectal	3/17
esophagus	5/13
fibroblast	1/1
gastric	4/16
kidney	6/21
liver	8/20
lung	20/75
lymphocyte	0/16
ovary	1/26
pancreas	4/24
peripheral nervous system	4/16
plasma cell	3/15
prostate	0/1
skin	7/24
soft tissue	3/9
thyroid	1/2
upper aerodigestive	7/22
urinary tract	10/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 626
Expression level (log2 read counts): 4.98

Expression Distribution

phosphatidylglycerophosphatase activity
cardiolipin biosynthetic process
phosphatidylglycerol biosynthetic process
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
cardiolipin metabolic process
phosphatidylglycerol metabolic process
protein tyrosine/serine/threonine phosphatase activity
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
regulation of intrinsic apoptotic signaling pathway
glycerophospholipid biosynthetic process
protein dephosphorylation
glycerolipid biosynthetic process
phospholipid biosynthetic process
glycerophospholipid metabolic process
dephosphorylation
phospholipid metabolic process
glycerolipid metabolic process
mitochondrial inner membrane
regulation of apoptotic signaling pathway
organophosphate biosynthetic process
lipid biosynthetic process
organophosphate metabolic process
cellular lipid metabolic process
lipid metabolic process
regulation of apoptotic process
regulation of programmed cell death
regulation of cell death
regulation of intracellular signal transduction