SEC31A

Gene Information

Official Symbol: SEC31A
Official Name: SEC31 homolog A, COPII coat complex component
Aliases and Previous Symbols: N/A
Entrez ID: 22872
UniProt: O94979
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dynasore 7μM R08 exp436	-3.98
Dynasore 10μM R04 exp180	-3.38
Cerivastatin 0.15μM R05 exp226	-3.13
Ethanol 0.01 R05 exp234	-3.11
Bortezomib 0.005μM R00 exp6	-2.99
Fluvastatin 2.2μM R06 exp282	-2.82
Cryptotanshinone 12μM R05 exp227	-2.81
Rapamycin 10μM R00 exp30	-2.64
Benzoate 10000μM R08 exp455	-2.22
Tunicamycin 0.04μM R07 exp418	-2.09
CB-5083 0.4μM R08 exp468	-2
B02 10μM R08 exp453	-1.98
Menadione 5μM R06 exp292	-1.88
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.83
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	-1.81
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-1.75
Chloramphenicol 2μM R00 exp12	1.76
Hydroxychloroquine 30μM R08 exp490	1.83
42°C R08 exp539	1.87
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.89
BH1 1μM R04 exp169	1.97
Doxorubicin 0.02μM R08 exp478	1.98
Nocodazole 0.2μM R02 exp64	1.98
Lead acetate 2000μM R08 exp497	2.12
Lead acetate 2000μM R08 exp498 no dilution day6	2.18
Oligomycin-A 20μM R00 exp26	2.21
Bafilomycin-A1 0.009μM R08 exp454	2.46
Etoposide 1μM R00 exp19	2.56
TRAIL 50ng/ml R00 exp36	2.98
Aminopterin 0.005μM R07 exp335	3.19
ABT-702 5μM plus CoCl2 18μM R07 exp320	3.22
Tubacin 1.6μM R07 exp416	3.41
Golgicide-A 4μM R03 exp122	4.24
TRAIL 5ng/ml R00 exp35	4.49
CoCl2 18μM R07 exp346	4.75

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14561
Expression level (log2 read counts): 6.62

Expression Distribution

Gene	Correlation
SEC23B	0.582
SAR1A	0.553
SEC16A	0.46
TMED2	0.455
USO1	0.424

vesicle coat
COPII-coated vesicle cargo loading
COPII vesicle coat
vesicle cargo loading
endoplasmic reticulum exit site
COPII-coated ER to Golgi transport vesicle
ER to Golgi transport vesicle membrane
endoplasmic reticulum organization
IRE1-mediated unfolded protein response
calcium-dependent protein binding
vesicle targeting, rough ER to cis-Golgi
COPII vesicle coating
vesicle coating
COPII-coated vesicle budding
vesicle targeting, to, from or within Golgi
Golgi vesicle budding
localization within membrane
vesicle targeting
vesicle budding from membrane
antigen processing and presentation of peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
endoplasmic reticulum unfolded protein response
cellular response to unfolded protein
cellular response to topologically incorrect protein
response to calcium ion
response to unfolded protein
establishment of vesicle localization
antigen processing and presentation of exogenous peptide antigen
antigen processing and presentation of exogenous antigen
vesicle localization
response to topologically incorrect protein
antigen processing and presentation of peptide antigen
structural molecule activity
endoplasmic reticulum to Golgi vesicle-mediated transport
antigen processing and presentation
response to endoplasmic reticulum stress
vesicle organization
establishment of organelle localization